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Neosensitization to Multiple Drugs Following Valproate-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.丙戊酸盐诱导的药物反应伴嗜酸性粒细胞增多和全身症状综合征后对多种药物的新致敏作用
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Drug neosensitization during anticonvulsant hypersensitivity syndrome.抗惊厥药超敏反应综合征期间的药物再致敏
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Non-aromatic Anticonvulsant (Divalproex Sodium)-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.非芳香族抗惊厥药（丙戊酸钠）引起的伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征。
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DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result.布赖尔综合征合并胞浆型抗中性粒细胞胞质抗体阳性患者，因应用丙戊酸钠而引发 DRESS 综合征，导致致命后果。
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Drug rash with eosinophilia and systemic symptoms induced by valproate and carbamazepine: formation of circulating auto-antibody against 190-kDa antigen.丙戊酸盐和卡马西平诱发的伴有嗜酸性粒细胞增多和全身症状的药物疹：针对190-kDa抗原的循环自身抗体的形成。
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A retrospective study of DRESS - drug reaction with eosinophilia and systemic symptoms.药物超敏反应伴嗜酸性粒细胞增多和全身症状的回顾性研究。
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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）：聚焦病毒在病理生理和诊断中的作用
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Successful use of carbamazepine in a patient with drug rash with eosinophilia and systemic symptoms.卡马西平成功用于一名患有药物疹伴嗜酸性粒细胞增多和全身症状的患者。
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本文引用的文献

1
Adverse drug reactions induced by valproic acid.丙戊酸所致药物不良反应。
Clin Biochem. 2013 Oct;46(15):1323-38. doi: 10.1016/j.clinbiochem.2013.06.012. Epub 2013 Jun 20.
2
DRESS syndrome: Part I. Clinical perspectives.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：第一部分. 临床观点。
J Am Acad Dermatol. 2013 May;68(5):693.e1-14; quiz 706-8. doi: 10.1016/j.jaad.2013.01.033.
3
Amoxicillin-Induced Hypersensitivity After DRESS To Carbamazepine.卡马西平致药物超敏反应综合征后阿莫西林致过敏。
World Allergy Organ J. 2010 Jul;3(7):220-2. doi: 10.1097/WOX.0b013e3181eab930.
4
The DRESS syndrome: a literature review.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：文献综述。
Am J Med. 2011 Jul;124(7):588-97. doi: 10.1016/j.amjmed.2011.01.017. Epub 2011 May 17.
5
Hypersensitivity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol: a possible co-sensitization.药物疹伴嗜酸性粒细胞增多和全身症状（DRESS）后对阿莫西林、卡马西平和别嘌醇过敏：一种可能的共同致敏。
Br J Clin Pharmacol. 2010 Aug;70(2):273-6. doi: 10.1111/j.1365-2125.2010.03685.x.
6
Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigine.抗癫痫药物引起的超敏综合征：卡马西平和拉莫三嗪之间可能存在交叉反应。
J Clin Pharmacol. 2009 Dec;49(12):1488-91. doi: 10.1177/0091270009344985. Epub 2009 Sep 1.
7
Cross-sensitivity of skin rashes with antiepileptic drug use.使用抗癫痫药物时皮疹的交叉敏感性。
Neurology. 2008 Nov 4;71(19):1527-34. doi: 10.1212/01.wnl.0000334295.50403.4c.
8
Drug neosensitization during anticonvulsant hypersensitivity syndrome.抗惊厥药超敏反应综合征期间的药物再致敏
J Investig Allergol Clin Immunol. 2006;16(5):321-6.
9
Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient.一名患者发生两种药物不良反应时细胞因子、嗜酸性粒细胞阳离子蛋白及免疫球蛋白谱的不同模式。
Pediatr Int. 2005 Dec;47(6):616-21. doi: 10.1111/j.1442-200x.2005.02143.x.
10
Valproic Acid and hypersensitivity syndrome.丙戊酸与超敏反应综合征。
Am J Psychiatry. 2004 Mar;161(3):579. doi: 10.1176/appi.ajp.161.3.579.

丙戊酸盐诱导的药物反应伴嗜酸性粒细胞增多和全身症状综合征后对多种药物的新致敏作用

Neosensitization to Multiple Drugs Following Valproate-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.

作者信息

Song Jae Min, Jung Young Eun, Park Joon Hyuk, Kim Moon Doo, Cheon Min Seok, Lee Chang In

机构信息

Department of Psychiatry, Jeju National University Hospital, Jeju, Republic of Korea.

Department of Psychiatry, School of Medicine, Jeju National University, Jeju, Republic of Korea.

出版信息

Psychiatry Investig. 2017 Jul;14(4):518-520. doi: 10.4306/pi.2017.14.4.518. Epub 2017 Jul 11.

DOI:10.4306/pi.2017.14.4.518
PMID:28845181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5561412/
Abstract

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is associated with severe skin eruptions, fever, hematological abnormalities, and multi-organ involvement. Although aromatic anticonvulsant drugs have been frequently associated with the manifestation of DRESS syndrome, its induction following treatment with nonaromatic anticonvulsants, such as valproate, has rarely been reported. Moreover, there are limited data regarding the development of neosensitization related to chemically unrelated drugs following an episode of DRESS syndrome. Here, a case of neosensitization to multiple drugs is described. The present case report describes a female patient who experienced neosensitization to amoxicillin, olanzapine, and quetiapine following the manifestation of DRESS syndrome induced by valproate.

摘要

药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征与严重皮疹、发热、血液学异常及多器官受累有关。尽管芳香族抗惊厥药物常与DRESS综合征的表现相关，但丙戊酸盐等非芳香族抗惊厥药物治疗后引发该综合征的情况鲜有报道。此外，关于DRESS综合征发作后对化学结构不相关药物发生新致敏反应的数据有限。在此，描述了一例对多种药物发生新致敏反应的病例。本病例报告描述了一名女性患者，在丙戊酸盐诱发DRESS综合征后，对阿莫西林、奥氮平和喹硫平发生了新致敏反应。