Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
Riv Psichiatr. 2017 Jul-Aug;52(4):172-173. doi: 10.1708/2737.27911.
The present report describes extrapyramidal side effects (EPS) appearing after 32 months of exclusive treatment with clozapine at low dosages. This case evidences that long-term treatment with clozapine may be associated with EPS and suggests that, even if clozapine is considered the medication with the fewest EPS and it is often prescribed as an effective treatment for them, its use does not fully eliminate the risk of neurological side effects.
本报告描述了在低剂量氯氮平单独治疗 32 个月后出现的锥体外系副作用（EPS）。该病例表明，长期使用氯氮平可能与 EPS 有关，并表明，即使氯氮平被认为是 EPS 最少的药物，并且经常被开为有效的治疗药物，但其使用并不能完全消除神经副作用的风险。
