Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital and University of Oulu, Oulu, Finland.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Clin Endocrinol (Oxf). 2017 Dec;87(6):673-679. doi: 10.1111/cen.13456. Epub 2017 Sep 21.
Hyperandrogenism, hyperinsulinaemia and obesity, known characteristics of polycystic ovary syndrome (PCOS), may influence bone mineral density and biochemical markers of bone turnover (BTMs) can provide a noninvasive assessment of bone turnover. To this end, the serum concentrations of BTMs and 25-hydroxyvitamin D (25OHD) were analysed in women with PCOS, and their possible associations with metabolic parameters of PCOS were determined.
Bone formation markers procollagen type I amino-terminal propeptide (PINP) and osteocalcin (OC), and bone resorption marker carboxy-terminal cross-linking telopeptide of type I collagen (CTX), along with 25OHD, were measured in 298 women with PCOS and 194 healthy controls.
Serum levels of PINP (47.0 ± 20.2 vs 58.1 ± 28.6 μg/L, P < .001) and OC (18.2 ± 7.5 vs 20.6 ± 9.8 μg/L, P < .001) were decreased in women with PCOS compared with controls, whereas no significant differences were found in CTX and 25OHD levels. Age-stratified analyses suggested that PINP (50.5 ± 21.7 vs 68.2 ± 26.6 μg/L, P < .001) and OC levels (20.4 ± 7.6 vs 25.5 ± 9.6 μg/L, P < .001) were decreased only in the younger age group (≤30 years) women with PCOS compared with controls. The formation markers and resorption marker decreased with age in both study groups.
Bone formation markers were decreased in younger women with PCOS when compared with healthy women, which may affect bone mass in these women.
多囊卵巢综合征（PCOS）的特征为高雄激素血症、高胰岛素血症和肥胖，这些因素可能会影响骨密度，而骨生化标志物（BTMs）可提供非侵入性的骨转换评估。为此，分析了患有 PCOS 女性的 BTMs 和 25-羟维生素 D（25OHD）血清浓度，并确定了它们与 PCOS 代谢参数的可能关联。
在 298 名患有 PCOS 的女性和 194 名健康对照者中测量了骨形成标志物Ⅰ型前胶原氨基端前肽（PINP）和骨钙素（OC），以及骨吸收标志物Ⅰ型胶原羧基端交联肽（CTX）和 25OHD。
与对照组相比，患有 PCOS 的女性血清 PINP（47.0±20.2 vs 58.1±28.6 μg/L，P<0.001）和 OC（18.2±7.5 vs 20.6±9.8 μg/L，P<0.001）水平降低，而 CTX 和 25OHD 水平无显著差异。年龄分层分析表明，仅在年轻（≤30 岁）的 PCOS 女性中，PINP（50.5±21.7 vs 68.2±26.6 μg/L，P<0.001）和 OC 水平（20.4±7.6 vs 25.5±9.6 μg/L，P<0.001）降低。两组研究对象的形成标志物和吸收标志物均随年龄增长而降低。
与健康女性相比，年轻的 PCOS 女性的骨形成标志物降低，这可能会影响这些女性的骨量。
