Taillan B, Barthelemy G, Routy J P, Pedinielli F J, Zarrouk F, Chardon H, Blanc A P
Pathol Biol (Paris). 1987 Apr;35(4):375-80.
This article is concerned with a prospective study about the systematical, simultaneous and comparative assay of four biological markers (carcino-embryonic antigen, lactate dehydrogenase, gammaglutamyl transferase and phosphohexose isomerase). This study was conducted in a department of Hematology and oncology on 258 patients. The dosage of each marker separately does not appear to be of diagnostical interest because of a lack of sensibility and specificity. But when there is a positive statistical correlation between several makers, their simultaneous dosage may allow the diagnostic of cancer and sometimes the determination of its origin.
本文是一项关于四种生物标志物（癌胚抗原、乳酸脱氢酶、γ-谷氨酰转移酶和磷酸己糖异构酶）的系统、同步和比较检测的前瞻性研究。该研究在血液学和肿瘤学科室对258名患者进行。由于缺乏敏感性和特异性，单独检测每种标志物似乎没有诊断价值。但是，当几种标志物之间存在正的统计学相关性时，它们的同步检测可能有助于癌症的诊断，有时还能确定其起源。
