Kairys Norah, Anastasopoulou Catherine, Schwell Ari
Temple University Hospital
Jefferson Einstein Medical Center
Cushing disease is an endocrine disorder characterized by increased adrenocorticotropic hormone (ACTH) production from the anterior pituitary, leading to excess cortisol release from the adrenal glands. A pituitary adenoma often causes this, or it results from excess production of corticotropin-releasing hormone (CRH) from the hypothalamus. Symptoms of the disease include generalized weakness, high blood pressure, diabetes mellitus, menstrual irregularities, or psychiatric changes. Physical manifestations of excess cortisol levels include moon facies, buffalo hump, easy bruising, abdominal striae, obesity, facial plethora, and hirsutism (see Cushing Syndrome). A key feature is that many patients with Cushing disease do not present with bitemporal hemianopsia because most lesions are pituitary microadenomas (less than 10mm in size).
库欣病是一种内分泌紊乱疾病，其特征是垂体前叶促肾上腺皮质激素（ACTH）分泌增加，导致肾上腺皮质醇释放过多。垂体腺瘤常导致这种情况，或者是由下丘脑促肾上腺皮质激素释放激素（CRH）分泌过多引起的。该病的症状包括全身无力、高血压、糖尿病、月经不调或精神变化。皮质醇水平过高的身体表现包括满月脸、水牛背、容易瘀伤、腹部条纹、肥胖、面部充血和多毛症（见库欣综合征）。一个关键特征是，许多库欣病患者没有双颞侧偏盲，因为大多数病变是垂体微腺瘤（大小小于10毫米）。
