轻度认知障碍和阿尔茨海默病中词汇提取的语音标记

Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease.

作者信息

Meilan Juan J G, Martinez-Sanchez Francisco, Carro Juan, Carcavilla Nuria, Ivanova Olga

机构信息

Faculty of Psychology, University of Salamanca, Campus Ciudad Jardin-Avenida de la Merced 109-131, 37005 Salamanca. Spain.

Faculty of Psychology, University of Murcia, Campus Universitario de Espinardo-30100 Murcia. Spain.

出版信息

Curr Alzheimer Res. 2018;15(2):111-119. doi: 10.2174/1567205014666170829112439.

DOI:10.2174/1567205014666170829112439

PMID:28847280

Abstract

BACKGROUND

Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subtype (aMCI), these voice- and speech-related symptoms are the first signs of AD. The purpose of this study is to verify whether these signs are related to deficits in lexical access, which appear early in AD.

METHOD

Anomic deficits in persons with MCI and AD are assessed through tests on verbal memory, denomination by confrontation, and verbal fluency. In addition, an acoustic analysis of speech is conducted in a reading task to identify the acoustic parameters associated with the groups analyzed, and their relation to the degree of anomic impairment observed in each one of them.

RESULTS AND CONCLUSIONS

The results show a direct relationship between the different acoustic parameters present in AD and the verbal fluency tests results.

摘要

背景

最近的研究已经确定了痴呆症与某些声音特征之间的相关性，例如嗓音和言语变化。声音特征可能是阿尔茨海默病（AD）的早期标志物。尽管这些与声音和言语相关的症状存在于非病理性衰老和轻度认知障碍中，尤其是在其遗忘型亚型（aMCI）中，但它们是AD的首要迹象。本研究的目的是验证这些迹象是否与词汇通达缺陷有关，而词汇通达缺陷在AD早期就会出现。