Meilan Juan J G, Martinez-Sanchez Francisco, Carro Juan, Carcavilla Nuria, Ivanova Olga
Faculty of Psychology, University of Salamanca, Campus Ciudad Jardin-Avenida de la Merced 109-131, 37005 Salamanca. Spain.
Faculty of Psychology, University of Murcia, Campus Universitario de Espinardo-30100 Murcia. Spain.
Curr Alzheimer Res. 2018;15(2):111-119. doi: 10.2174/1567205014666170829112439.
Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subtype (aMCI), these voice- and speech-related symptoms are the first signs of AD. The purpose of this study is to verify whether these signs are related to deficits in lexical access, which appear early in AD.
Anomic deficits in persons with MCI and AD are assessed through tests on verbal memory, denomination by confrontation, and verbal fluency. In addition, an acoustic analysis of speech is conducted in a reading task to identify the acoustic parameters associated with the groups analyzed, and their relation to the degree of anomic impairment observed in each one of them.
The results show a direct relationship between the different acoustic parameters present in AD and the verbal fluency tests results.
最近的研究已经确定了痴呆症与某些声音特征之间的相关性，例如嗓音和言语变化。声音特征可能是阿尔茨海默病（AD）的早期标志物。尽管这些与声音和言语相关的症状存在于非病理性衰老和轻度认知障碍中，尤其是在其遗忘型亚型（aMCI）中，但它们是AD的首要迹象。本研究的目的是验证这些迹象是否与词汇通达缺陷有关，而词汇通达缺陷在AD早期就会出现。
通过对言语记忆、面对面对物体命名和言语流畅性的测试，评估MCI和AD患者的命名障碍。此外，在阅读任务中对言语进行声学分析，以确定与所分析组相关的声学参数，以及它们与在每组中观察到的命名障碍程度的关系。
结果表明，AD中存在的不同声学参数与言语流畅性测试结果之间存在直接关系。
