Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.
Department of Pharmacology, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Drug Discov Today. 2017 Dec;22(12):1816-1824. doi: 10.1016/j.drudis.2017.08.005. Epub 2017 Aug 26.
The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.
Ran 结合蛋白微管组织中心（RanBPM）是一种高度保守的核质蛋白，参与多种细胞内信号通路，控制着多种细胞功能。RanBPM 与与多种疾病相关的蛋白质相互作用，包括阿尔茨海默病（AD）、精神分裂症（SCZ）和癌症。本文定义了支架蛋白 RanBPM 的特征，并重点介绍了其在多种生理疾病（如神经疾病、生育障碍和癌症）中的相互作用伙伴。
