Oncol Res Treat. 2017;40(9):533-539. doi: 10.1159/000475502. Epub 2017 Aug 21.
This study explores correlations of galectin-3 gene polymorphisms (rs4644, rs4652, and rs11125) with cervical cancer risk and prognosis in Chinese populations.
A total of 126 patients with cervical cancer were selected to form the case group, and 102 healthy people were selected for the control group following a physical examination. 3 polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
The distribution frequencies of the CC+CA genotype of rs4652 and the AT+TT genotype of rs11125 in the case group were remarkably higher than those in the control group. rs4644 only had correlations with tumor diameter, while rs4652 and rs11125 had correlations with tumor diameter, FIGO staging, differentiation grades, clinical staging, lymph node metastasis (LNM), and treatment modality. The 5-years survival rate of patients with CC+CA of rs4652 was lower but the recurrence rate was higher compared to AA type patients. In contrast, AA type patients with rs11125 had a higher 5-year survival rate but a lower recurrence rate than those of AT+TT type. CC+CA genotype of rs4652, AT+TT genotype of rs11125, and treatment modality were independent factors related to overall survival and disease-free survival, and LNM was an independent factor related to OS.
Our findings provide evidence that allele C of rs4652 and allele T of rs11125 in the galectin-3 gene may be risk factors for cervical cancer.
本研究旨在探讨半乳糖凝集素-3 基因多态性（rs4644、rs4652 和 rs11125）与中国人群宫颈癌风险和预后的相关性。
选择 126 例宫颈癌患者作为病例组，102 例健康体检者作为对照组。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测 3 个多态性。
病例组 rs4652 的 CC+CA 基因型和 rs11125 的 AT+TT 基因型分布频率明显高于对照组。rs4644 仅与肿瘤直径相关，而 rs4652 和 rs11125 与肿瘤直径、FIGO 分期、分化程度、临床分期、淋巴结转移（LNM）和治疗方式相关。rs4652 的 CC+CA 基因型患者的 5 年生存率较低，但复发率较高；而 rs11125 的 AA 型患者 5 年生存率较高，但复发率较低。rs4652 的 CC+CA 基因型、rs11125 的 AT+TT 基因型和治疗方式是总生存和无病生存的独立相关因素，LNM 是 OS 的独立相关因素。
本研究结果表明，半乳糖凝集素-3 基因 rs4652 的等位基因 C 和 rs11125 的等位基因 T 可能是宫颈癌的风险因素。
