• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

“展望”试验:将经验教训转化为临床实践与进一步研究

The Look AHEAD Trial: Translating Lessons Learned Into Clinical Practice and Further Study.

作者信息

Salvia Meg G

机构信息

Meg Salvia Nutrition, Walden Behavioral Care, Cambridge, MA.

出版信息

Diabetes Spectr. 2017 Aug;30(3):166-170. doi: 10.2337/ds17-0016.

DOI:10.2337/ds17-0016
PMID:28848309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5556585/
Abstract

Although the Look AHEAD (Action for Health in Diabetes) trial, which spanned more than 8 years, did not find significant differences in cardiovascular morbidity and mortality between study groups, it did demonstrate significant differences in weight loss and maintenance. Using lessons learned from the Look AHEAD protocol, clinicians can help people with type 2 diabetes lose weight, improve glucose management, increase physical activity, alter eating patterns, and support long-term positive health outcomes. It remains important, however, to avoid assigning a higher priority to weight loss goals than to improvements in glucose management, long-term health outcomes, and quality of life.

摘要

尽管为期8年多的“糖尿病健康行动”(Look AHEAD)试验并未发现研究组之间在心血管疾病发病率和死亡率方面存在显著差异,但确实显示出在体重减轻和维持方面存在显著差异。借鉴“糖尿病健康行动”方案中的经验教训,临床医生可以帮助2型糖尿病患者减轻体重、改善血糖管理、增加体育活动、改变饮食模式,并支持长期的积极健康成果。然而,避免将减重目标置于比改善血糖管理、长期健康成果和生活质量更高的优先级仍然很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fba/5556585/981b3ec39062/166f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fba/5556585/981b3ec39062/166f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fba/5556585/981b3ec39062/166f1.jpg

相似文献

1
The Look AHEAD Trial: Translating Lessons Learned Into Clinical Practice and Further Study.“展望”试验:将经验教训转化为临床实践与进一步研究
Diabetes Spectr. 2017 Aug;30(3):166-170. doi: 10.2337/ds17-0016.
2
Weight Changes in General Practice.全科医疗中的体重变化
Dan Med J. 2017 Jun;64(6).
3
4
The Look AHEAD Trial: Implications for Lifestyle Intervention in Type 2 Diabetes Mellitus.“展望”试验:对2型糖尿病生活方式干预的启示
Prog Cardiovasc Dis. 2015 Jul-Aug;58(1):69-75. doi: 10.1016/j.pcad.2015.04.002. Epub 2015 Apr 30.
5
The results of Look AHEAD do not row against the implementation of lifestyle changes in patients with type 2 diabetes.这些结果与对 2 型糖尿病患者实施生活方式改变的建议并不相悖。
Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):4-9. doi: 10.1016/j.numecd.2013.12.001. Epub 2013 Dec 20.
6
Effects of a long-term lifestyle modification programme on peripheral neuropathy in overweight or obese adults with type 2 diabetes: the Look AHEAD study.长期生活方式改变计划对超重或肥胖的2型糖尿病成年患者周围神经病变的影响:糖尿病预防计划(Look AHEAD)研究
Diabetologia. 2017 Jun;60(6):980-988. doi: 10.1007/s00125-017-4253-z. Epub 2017 Mar 27.
7
8
Effects of behavioral treatment on long-term weight loss: lessons learned from the look AHEAD trial.行为治疗对长期体重减轻的影响:从“健康体重提升与高血压预防(Look AHEAD)”试验中获得的经验教训
Obesity (Silver Spring). 2014 Jan;22(1):3-4. doi: 10.1002/oby.20672.
9
10
Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial.强化生活方式干预可改善2型糖尿病患者自我报告的胃肠道症状:糖尿病健康行动(Look AHEAD)临床试验结果
Clin Diabetes. 2015 Oct;33(4):181-8. doi: 10.2337/diaclin.33.4.181.

引用本文的文献

1
Metformin use in prediabetes: A review of evidence and a focus on metabolic features among peri-menopausal women.二甲双胍在糖尿病前期的应用:证据综述及对围绝经期女性代谢特征的关注
Diabetes Obes Metab. 2025 Jun;27 Suppl 3:3-15. doi: 10.1111/dom.16442. Epub 2025 May 6.
2
Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort.“展望”队列中肥胖程度降低与糖化血红蛋白水平降低及胰岛素使用减少之间的关联。
Obesity (Silver Spring). 2025 Mar;33(3):612-620. doi: 10.1002/oby.24242. Epub 2025 Feb 4.
3
Behavioral approaches to nutrition and eating patterns for managing type 2 diabetes: A review.

本文引用的文献

1
Does weight cycling promote obesity and metabolic risk factors?体重循环会促进肥胖和代谢风险因素吗?
Obes Res Clin Pract. 2017 Mar-Apr;11(2):131-139. doi: 10.1016/j.orcp.2016.10.284. Epub 2016 Oct 20.
2
Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial.体重减轻维持及体重反弹与心血管疾病危险因素4年变化的关联:糖尿病健康行动(Look AHEAD)临床试验
Diabetes Care. 2016 Aug;39(8):1345-55. doi: 10.2337/dc16-0509. Epub 2016 Jun 6.
3
Improving diabetes outcomes through lifestyle change--A randomized controlled trial.
用于管理2型糖尿病的营养和饮食模式的行为方法:综述
Am J Med Open. 2023 Jan 28;9:100034. doi: 10.1016/j.ajmo.2023.100034. eCollection 2023 Jun.
4
Cardiometabolic and immune response to exercise training in patients with metabolic syndrome: retrospective analysis of two randomized clinical trials.代谢综合征患者对运动训练的心脏代谢和免疫反应:两项随机临床试验的回顾性分析
Front Cardiovasc Med. 2024 Apr 3;11:1329633. doi: 10.3389/fcvm.2024.1329633. eCollection 2024.
5
A review of the evidence on cardiovascular outcomes from obesity treatment.肥胖治疗对心血管结局影响的证据综述。
Obes Pillars. 2023 May 20;7:100071. doi: 10.1016/j.obpill.2023.100071. eCollection 2023 Sep.
6
BrazIliaN Type 1 & 2 DiabetEs Disease Registry (BINDER): longitudinal, real-world study of diabetes mellitus control in Brazil.巴西1型和2型糖尿病疾病登记处(BINDER):巴西糖尿病控制的纵向真实世界研究。
Front Clin Diabetes Healthc. 2022 Aug 16;3:934629. doi: 10.3389/fcdhc.2022.934629. eCollection 2022.
7
Surgical treatment of obesity and excess risk of developing heart failure in a controlled cohort study.在一项对照队列研究中,肥胖症的手术治疗与心力衰竭风险增加的关系。
ESC Heart Fail. 2022 Jun;9(3):1844-1852. doi: 10.1002/ehf2.13880. Epub 2022 Mar 11.
8
Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD-11.度拉糖肽3.0毫克和4.5毫克对2型糖尿病患者体重的影响:AWARD - 11探索性分析
Diabetes Obes Metab. 2021 Oct;23(10):2242-2250. doi: 10.1111/dom.14465. Epub 2021 Jun 29.
9
Pragmatic Evaluation of a Health System-Based Employee Weight Management Program.基于健康系统的员工体重管理计划的实用评估
Int J Environ Res Public Health. 2021 May 31;18(11):5901. doi: 10.3390/ijerph18115901.
10
Factors Determining the Success of Therapeutic Lifestyle Interventions in Diabetes - Role of Partner and Family Support.决定糖尿病治疗性生活方式干预成功的因素——伴侣及家庭支持的作用
Eur Endocrinol. 2019 Apr;15(1):18-24. doi: 10.17925/EE.2019.15.1.18. Epub 2019 Apr 12.
通过生活方式改变改善糖尿病预后——一项随机对照试验。
Obesity (Silver Spring). 2015 Sep;23(9):1792-9. doi: 10.1002/oby.21172. Epub 2015 Aug 11.
4
Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later.生活方式干预头两个月的体重变化可预测8年后的体重变化。
Obesity (Silver Spring). 2015 Jul;23(7):1353-6. doi: 10.1002/oby.21112.
5
Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials.超重和肥胖的2型糖尿病成年患者的生活方式减肥干预效果:一项随机临床试验的系统评价和荟萃分析
J Acad Nutr Diet. 2015 Sep;115(9):1447-63. doi: 10.1016/j.jand.2015.02.031. Epub 2015 Apr 29.
6
Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial.长期行为体重管理干预对 2 型糖尿病超重或肥胖患者肾病的影响: LOOK AHEAD 随机临床试验的二次分析。
Lancet Diabetes Endocrinol. 2014 Oct;2(10):801-9. doi: 10.1016/S2213-8587(14)70156-1. Epub 2014 Aug 10.
7
Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial.强化生活方式干预对2型糖尿病患者抑郁及健康相关生活质量的影响:糖尿病预防计划(Look AHEAD)试验
Diabetes Care. 2014 Jun;37(6):1544-53. doi: 10.2337/dc13-1928.
8
Nutrition therapy recommendations for the management of adults with diabetes.成人糖尿病管理的营养治疗建议。
Diabetes Care. 2014 Jan;37 Suppl 1:S120-43. doi: 10.2337/dc14-S120.
9
Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study.强化生活方式干预的 8 年体重减轻效果:LOOK AHEAD 研究。
Obesity (Silver Spring). 2014 Jan;22(1):5-13. doi: 10.1002/oby.20662.
10
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.2 型糖尿病强化生活方式干预的心血管效应。
N Engl J Med. 2013 Jul 11;369(2):145-54. doi: 10.1056/NEJMoa1212914. Epub 2013 Jun 24.