Barral-Netto M, Cardoso S A, Barral A
Acta Trop. 1987 Mar;44(1):5-11.
We have infected BALB/c and C57BL/6 mice with a cloned Leishmania mexicana amazonensis population, obtained from the "Maria" strain. Progression of infection and histopathological examination confirmed the extreme susceptibility of BALB/c mice and the resistant pattern of the C57 BL/6. Anti-Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice through the period of infection. Tests of delayed type hypersensitivity reaction with Leishmania antigens were positive in both strains in the beginning of the infection, but were negative later on in BALB/c mice. Our results are similar to those obtained with mixed parasite populations, and rule out the possibility of selection among different parasite subpopulations as responsible for the divergent course of the disease exhibited by these two strains of mice.
我们用从“玛丽亚”菌株获得的克隆亚马逊利什曼原虫种群感染了BALB/c和C57BL/6小鼠。感染进程和组织病理学检查证实BALB/c小鼠极度易感，而C57BL/6小鼠呈现抗性模式。在整个感染期间，BALB/c小鼠的抗利什曼原虫抗体滴度高于C57BL/6小鼠。用利什曼原虫抗原进行的迟发型超敏反应试验在感染初期在两种品系中均为阳性，但后来在BALB/c小鼠中转为阴性。我们的结果与用混合寄生虫种群获得的结果相似，并排除了在不同寄生虫亚群中进行选择导致这两种品系小鼠疾病进程不同的可能性。
