葡萄牙慢性丙型肝炎患者的健康相关生活质量
Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C.
作者信息
Rei Andreia, Rocha Marta, Pedroto Isabel
机构信息
Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Medical College, University of Porto (UP), Porto, Portugal.
Gastroenterology Department, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.
出版信息
GE Port J Gastroenterol. 2017 Mar;24(2):68-78. doi: 10.1159/000450875. Epub 2016 Dec 3.
INTRODUCTION
Chronic hepatitis C virus (HCV) infection impacts multiple health and psychosocial dimensions and encompasses a significant overall burden as it progresses to advanced stages of hepatic disease.
AIMS
To evaluate for the first time health-related quality of life (HRQoL) of a subset of Portuguese adult patients with chronic hepatitis C using the Portuguese versions of generic, Short-Form 12 Health Survey (SF-12v2), and disease-specific, Chronic Liver Disease Questionnaire (CLDQ), instruments; to assess psychometric properties of CLDQ, Portuguese version.
METHODS
HRQoL was evaluated in Portuguese adult outpatients with chronic hepatitis C attending the Hepatology Clinic at Centro Hospitalar do Porto, using SF-12v2 and CLDQ. This transversal study was conducted between April and October 2015.
RESULTS
Eighty outpatients with chronic hepatitis C were enrolled, with mean age 57 years (standard deviation 11), 67.5% male, all Caucasian, 76.3% diagnosed for >10 years, 66.3% with C virus genotype 1, 65.0% with hepatic cirrhosis (94.2% of which Child-Pugh A), and 46.3% under current antiviral treatment. For CLDQ internal consistency, Cronbach's α was 0.88; for construct validity, correlations ranged from 0.36 to 0.80 ( < 0.01). Mean CLDQ scores ranged from 4.25 (Worry) to 5.78 (Abdominal Symptoms). Lower scores were observed for Worry, Fatigue, and Emotional Function domains. Statistically significant differences were found in median values of Worry (CLDQ) and Role Emotional (SF-12) ( < 0.05) for "current antiviral treatment," with higher scores for patients that concluded therapy.
CONCLUSION
HRQoL was negatively affected in several domains in Portuguese patients with chronic hepatitis C; oral antiviral treatment correlated with better quality of life, assuring its benefits on this population; the CLDQ Portuguese version revealed adequate psychometric properties, and was useful in assessing quality of life in Portuguese HCV patients.
引言
慢性丙型肝炎病毒（HCV）感染会影响多个健康和心理社会层面，并且随着病情发展到肝病晚期，总体负担会显著加重。
目的
首次使用通用的葡萄牙语版简短健康调查问卷（SF - 12v2）和特定疾病的葡萄牙语版慢性肝病问卷（CLDQ）工具，评估一部分葡萄牙成年慢性丙型肝炎患者的健康相关生活质量（HRQoL）；评估葡萄牙语版CLDQ的心理测量特性。
方法
使用SF - 12v2和CLDQ对在波尔图中心医院肝病门诊就诊的葡萄牙成年慢性丙型肝炎门诊患者的HRQoL进行评估。这项横断面研究于2015年4月至10月进行。
结果
纳入了80例慢性丙型肝炎门诊患者，平均年龄57岁（标准差11），67.5%为男性，均为白种人，76.3%被诊断超过10年，66.3%为丙型肝炎病毒基因1型，65.0%患有肝硬化（其中94.2%为Child - Pugh A级），46.3%正在接受当前的抗病毒治疗。对于CLDQ，Cronbach's α为0.88，表明内部一致性；对于结构效度，相关性范围为0.36至0.80（P < 0.01）。CLDQ平均得分范围为4.25（担忧）至5.78（腹部症状）。在担忧、疲劳和情绪功能领域观察到较低得分。对于“当前抗病毒治疗”，在担忧（CLDQ）和角色情绪（SF - 12）的中位数方面发现有统计学显著差异（P < 0.05），完成治疗的患者得分更高。
结论
葡萄牙慢性丙型肝炎患者的HRQoL在几个领域受到负面影响；口服抗病毒治疗与更好的生活质量相关，证实了其对该人群的益处；葡萄牙语版CLDQ显示出足够的心理测量特性，并且有助于评估葡萄牙丙型肝炎患者的生活质量。
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