Postow Lisa, Punturieri Antonella, Croxton Thomas L, Weinmann Gail G, Kiley James P
Division of Lung Diseases. National Heart, Lung, and Blood Institute. National Institutes of Health. Bethesda, MD 20892-7952.
Chronic Obstr Pulm Dis. 2014 May 6;1(1):64-72. doi: 10.15326/jcopdf.1.1.2014.0123.
The past decade of research in chronic obstructive pulmonary disease (COPD) has seen a new age of understanding both pathogenic mechanisms and clinical manifestations of the disease. The National Heart, Lung, and Blood Institute (NHLBI) has helped guide this progress with a series of initiatives to stimulate COPD research in various ways. These initiatives were designed to promote a precision medicine approach to treating COPD, one that takes advantage of targeting particular molecular pathways and the individual pathobiologies of the diversity of COPD patients. This review describes the strategic objectives of these initiatives, as well as some of their observed and anticipated outcomes. In addition, we address parallel steps NHLBI has taken to promote COPD awareness among the public. As we look toward the immediate future of COPD research and education, we see a time of great progress in terms of understanding and treatment. Furthermore, while this remains a debilitating and disturbingly prevalent disease, as NHLBI looks even farther ahead, we envision emerging efforts toward COPD prevention.
过去十年对慢性阻塞性肺疾病(COPD)的研究开启了一个理解该疾病发病机制和临床表现的新时代。美国国立心肺血液研究所(NHLBI)通过一系列举措以各种方式推动COPD研究,助力了这一进程。这些举措旨在推动采用精准医学方法治疗COPD,即利用针对特定分子途径以及COPD患者多样性的个体病理生物学特性的方法。本综述描述了这些举措的战略目标以及一些已观察到的和预期的成果。此外,我们阐述了NHLBI为提高公众对COPD的认识而采取的并行措施。展望COPD研究和教育的近期未来,我们看到在理解和治疗方面将取得巨大进展。此外,尽管这仍然是一种使人衰弱且令人不安地普遍存在的疾病,但随着NHLBI展望更远的未来,我们设想将出现针对COPD预防的新努力。