Perlin J B, Lothman E W, Geary W A
Ann Neurol. 1987 May;21(5):475-80. doi: 10.1002/ana.410210511.
The role of the neuropeptide somatostatin in limbic seizures was studied using electrical stimulation of the hippocampus in kindled rats. Cysteamine, an agent which selectively and reversibly depletes brain somatostatin stores, had a biphasic action. An early proconvulsant effect was seen within a few hours, consisting of prolonged electrographic seizures in the hippocampus and more severe behavioral convulsions. A later anticonvulsant effect, maximal at 1 to 2 days and dissipating within a week, was manifested by less intense behavioral convulsions without change in the duration of electrical seizure activity. Both effects were dose-dependent. No change in afterdischarge thresholds was detected at any time after the administration of cysteamine. Intraventricular administration of somatostatin to animals with behavioral seizures attenuated by cysteamine treatment restored the responses to precysteamine levels. We conclude that somatostatin facilitates the spread of seizures over limbic circuits from a region of focal seizure initiation.
利用电刺激点燃大鼠的海马体，研究了神经肽生长抑素在边缘叶癫痫中的作用。半胱胺是一种能选择性且可逆地耗尽脑内生长抑素储备的药物，它具有双相作用。在数小时内可观察到早期促惊厥作用，表现为海马体中脑电图癫痫发作时间延长以及更严重的行为性惊厥。后期抗惊厥作用在1至2天达到最大，并在一周内消散，表现为行为性惊厥强度减弱，而电惊厥活动持续时间无变化。两种作用均呈剂量依赖性。在给予半胱胺后的任何时间，均未检测到放电阈值的变化。对经半胱胺治疗行为性惊厥减轻的动物进行脑室内注射生长抑素，可使反应恢复到注射半胱胺前的水平。我们得出结论，生长抑素促进癫痫从局灶性癫痫起始区域在边缘叶回路中传播。
