Department of Pharmacy Practice, College of Pharmacy, Midwestern University, 19555 N. 59th Ave., Glendale, AZ, 85308, USA.
Am J Cardiovasc Drugs. 2018 Feb;18(1):65-71. doi: 10.1007/s40256-017-0247-y.
An estimated 27.8% of the United States (US) population aged ≥20 years has hyperlipidemia, defined as total serum cholesterol of ≥240 mg/dL. A previous study of US physician office visits for hyperlipidemia in 2005 found both suboptimal compliance and racial/ethnic disparities in screening and treatment.
The aim was to estimate current rates of laboratory testing, lifestyle education, and pharmacotherapy for hyperlipidemia.
Data were derived from the US National Ambulatory Medical Care Survey (NAMCS), a nationally representative study of office-based physician visits, for 2013-2014. Patients aged ≥20 years with a primary or secondary diagnosis of hyperlipidemia were sampled. Study outcomes included receipt or ordering of total cholesterol testing, diet/nutrition counseling, exercise counseling, and pharmacotherapy prescription including statins, ezetimibe, omega-3 fatty acids, niacin, or combination therapies.
Compared with previously reported results for 2005, rates of pharmacotherapy have remained static (52.2 vs. 54.6% for 2005 and 2013-2014, respectively), while rates of lifestyle education have markedly declined for diet/nutrition (from 39.7 to 22.4%) and exercise (from 32.1 to 16.0%). Lifestyle education did not vary appreciably by race/ethnicity in 2013-2014. However, rates of lipid testing were much higher for whites (41.6%) than for blacks (29.9%) or Hispanics (34.2%). Tobacco education was ordered/provided in only 4.0% of office visits.
Compliance with guidelines for the screening and treatment of hyperlipidemia remains suboptimal, and rates of lifestyle education have declined since 2005. There exists an urgent need for enhanced levels of provider intervention to reduce the morbidity and mortality associated with hyperlipidemia.
据估计,美国(US)年龄≥20 岁的人口中有 27.8%患有高脂血症,定义为血清总胆固醇≥240mg/dL。之前对 2005 年美国医生办公室就诊治疗高脂血症的研究发现,在筛查和治疗方面存在不达标和种族/民族差异。
旨在评估目前高脂血症实验室检测、生活方式教育和药物治疗的比例。
数据来源于美国国家门诊医疗调查(NAMCS),这是一项针对医生办公室就诊的全国代表性研究,研究对象为 2013-2014 年年龄≥20 岁的原发性或继发性高脂血症患者。研究结果包括总胆固醇检测、饮食/营养咨询、运动咨询以及他汀类药物、依折麦布、ω-3 脂肪酸、烟酸或联合治疗等药物治疗处方的接受或开具情况。
与之前报道的 2005 年结果相比,药物治疗的比例保持不变(2005 年和 2013-2014 年分别为 52.2%和 54.6%),而饮食/营养(从 39.7%降至 22.4%)和运动(从 32.1%降至 16.0%)的生活方式教育的比例显著下降。2013-2014 年,生活方式教育在种族/民族之间没有明显差异。然而,白人(41.6%)的血脂检测率明显高于黑人(29.9%)或西班牙裔(34.2%)。仅 4.0%的就诊提供/开具了烟草教育。
高脂血症的筛查和治疗指南的遵守情况仍不理想,自 2005 年以来,生活方式教育的比例有所下降。迫切需要加强提供者的干预措施,以降低与高脂血症相关的发病率和死亡率。