Dhasmana K M, Banerjee A K, Erdmann W
Arch Int Pharmacodyn Ther. 1987 Mar;286(1):152-61.
This paper reports investigations on the effects on gastrointestinal transit of subcutaneous or intrathecal administration of opiates: morphine, sufentanil and alfentanil. Subcutaneous administration of opiates produced a significant dose-dependent decrease in transit of a charcoal meal test. Intrathecal administration of morphine to Wistar rats with catheter chronically implanted in the subarachnoid space did not cause a decrease in gastrointestinal transit. However, in freshly prepared rats with intrathecal catheter in the subarachnoid space, morphine significantly decreased intestinal transit of charcoal meal. In addition, sufentanil and alfentanil, on intrathecal administration in rats with chronically implanted catheters, caused a marked dose-dependent slowing of the passage of meal. Prior s.c. administration of the opiate antagonist naloxone completely blocked the depression of gastrointestinal transit caused by high doses of intrathecal sufentanil and s.c. administered morphine.
本文报道了皮下或鞘内注射阿片类药物（吗啡、舒芬太尼和阿芬太尼）对胃肠转运影响的研究。皮下注射阿片类药物使炭末餐试验中的转运显著呈剂量依赖性降低。给蛛网膜下腔长期植入导管的Wistar大鼠鞘内注射吗啡，并未导致胃肠转运降低。然而，在蛛网膜下腔刚植入鞘内导管的大鼠中，吗啡显著降低了炭末餐的肠道转运。此外，给长期植入导管的大鼠鞘内注射舒芬太尼和阿芬太尼，导致餐食通过明显呈剂量依赖性减慢。预先皮下注射阿片类拮抗剂纳洛酮，完全阻断了高剂量鞘内注射舒芬太尼和皮下注射吗啡所致的胃肠转运抑制。
