基于奎宁的三功能有机催化剂用于串联aza-Henry 反应-环化反应：螺环吲哚-吡咯烷/哌啶的不对称合成。
Quinine-Based Trifunctional Organocatalyst for Tandem Aza-Henry Reaction-Cyclization: Asymmetric Synthesis of Spiroxindole-Pyrrolidine/Piperidines.
机构信息
Centre of Biomedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus , Raebareli Road, Lucknow 226014, UP, India.
Department of Chemistry, Indian Institute of Technology Kharagpur (IIT Kharagpur) , Kharagpur 721302, WB, India.
出版信息
Org Lett. 2017 Sep 15;19(18):4778-4781. doi: 10.1021/acs.orglett.7b02150. Epub 2017 Aug 29.
A quinine-derived trifunctional sulphonamide catalyst has been developed for the effective asymmetric organocatalytic tandem aza-Henry reaction-cyclization of isatin-derived ketimines and nitroalkane-mesylates for the synthesis of spiro-pyrrolidine/piperidine-oxindoles. Demethylation of traditional bifunctional catalyst to incorporate an additional hydrogen bonding C6'-OH group plays the key role toward remarkable enantioselectivity.
一种来源于奎宁的三官能化磺酰胺催化剂已被开发出来，用于有效的不对称有机催化串联氮杂 Henry 反应-环化反应，该反应由色胺衍生的酮亚胺和硝基烷-甲磺酸酯组成，用于合成螺吡咯烷/哌啶-氧吲哚。将传统的双功能催化剂脱甲基以引入额外的氢键 C6'-OH 基团，这对获得显著的对映选择性起着关键作用。
Zotero 插件