HIV感染儿童中双倍剂量与标准剂量乙肝疫苗的随机对照试验
Double Dose Versus Standard Dose Hepatitis B Vaccine in HIV-infected Children: A Randomized Controlled Trial.
作者信息
Siddiqui Shahid Akhtar, Maurya Manisha, Singh D K, Srivastava Anubha, Rai Ruchi
机构信息
Department of Pediatrics, MLN Medical College, Allahabad, Uttar Pradesh, India. Correspondence to: Prof Ruchi Rai, A-77, Sector 21, Jalvayu Vihar, NOIDA 201303, Uttar Pradesh, India.
出版信息
Indian Pediatr. 2017 Dec 15;54(12):1017-1020. doi: 10.1007/s13312-017-1203-2. Epub 2017 Aug 24.
OBJECTIVE
To compare the efficacy of double dose (20 µg) with standard dose (10 µg) of hepatitis B vaccine in HIV-infected children.
METHODS
Unvaccinated HIV-infected children were randomized to receive 3 doses of double dose (N=27) or standard dose (N=28) of recombinant Hepatitis B vaccine. Anti-HBs antibody titres were measured 3 mo after the last dose. An antibody titre ≥10 mIU/mL 12 weaks after the third dose was considered as serporotection.
RESULTS
Seroprotection was achieved by 17 (60.7%) children in standard dose group against 20 (74%) in the double dose group [RR (95%CI) 0.8 (0.17-1.7); P=0.29]. CD4 count < 500 cells/mm3 was significantly associated with lower rates of seroprotection.
CONCLUSION
Double dose of hepatitis B vaccine does not seem to provide any advantage when compared to standard dose in HIV-infected children.
目的
比较双倍剂量（20微克）与标准剂量（10微克）乙肝疫苗对感染HIV儿童的疗效。
方法
未接种疫苗的感染HIV儿童被随机分为两组，分别接受3剂双倍剂量（N = 27）或标准剂量（N = 28）的重组乙肝疫苗。在最后一剂疫苗接种3个月后测量抗-HBs抗体滴度。第三剂疫苗接种12周后抗体滴度≥10 mIU/mL被视为血清保护。
结果
标准剂量组有17名（60.7%）儿童获得血清保护，双倍剂量组有20名（74%）儿童获得血清保护[相对危险度（95%置信区间）0.8（0.17 - 1.7）；P = 0.29]。CD4细胞计数<500个细胞/mm³与血清保护率较低显著相关。
结论
与标准剂量相比，双倍剂量的乙肝疫苗对感染HIV的儿童似乎没有任何优势。
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