1 Department of Cardiology and Intensive Care, St Josef Hospital Braunau, Austria.
2 Department of Cardiology, Ziekenhuis Oost-Limburg, Belgium.
Eur Heart J Acute Cardiovasc Care. 2018 Dec;7(8):739-742. doi: 10.1177/2048872617728721. Epub 2017 Aug 29.
Acute kidney injury (AKI), mostly defined as a rise in serum creatinine concentration of more than 0.5 mg/dl, is a common, serious, and potentially preventable complication of percutaneous coronary intervention and is associated with adverse outcomes including an increased risk of inhospital mortality. Recent data from the National Cardiovascular Data Registry/Cath-PCI registry including 985,737 consecutive patients undergoing percutaneous coronary intervention suggest that approximately 7% experienced AKI with a reported incidence of 3-19%. In patients undergoing primary percutaneous coronary intervention for acute myocardial infarction (AMI), AKI occurs more frequently with rates up to 20% depending on patient and procedural characteristics. However, varying definitions of AKI limit comparisons of AKI rates across different studies. Recently, most studies have adopted the Acute Kidney Injury Network (AKIN) criteria for definition and classification of AKI. Beyond the AKIN criteria for AKI, other classifications such as the risk, injury, failure, loss and end-stage kidney disease (RIFLE) and kidney disease: improving global outcomes (KDIGO) criteria are used to define AKI. Notably, even small increases in serum creatinine beyond AKI may be associated with adverse outcomes including increased hospital length of stay and excess. Acute kidney injury (AKI) is a serious and potentially preventable complication of percutaneous coronary intervention (PCI). Worsening renal function is associated with adverse outcomes including a higher rate of in-hospital mortality. In patients undergoing primary PCI for acute myocardial infarction (AMI), AKI occurs up to 20% of such individuals. Varying definitions of AKI limit comparisons of AKI rates across different studies. Additionally, even small increases in serum creatinine beyond lavels meeting AKI definitions may be associated with adverse outcomes including increased hospital length of stay.
急性肾损伤（AKI），主要定义为血清肌酐浓度升高超过 0.5mg/dl，是经皮冠状动脉介入治疗（PCI）的常见、严重且潜在可预防的并发症，与不良结局相关，包括住院死亡率增加。国家心血管数据注册中心/ Cath-PCI 注册中心最近的数据包括 985737 例连续接受 PCI 的患者，表明约有 7%的患者发生 AKI，报告的发生率为 3-19%。在因急性心肌梗死（AMI）而行直接经皮冠状动脉介入治疗的患者中，AKI 的发生率更高，取决于患者和手术特点，其发生率高达 20%。然而，AKI 的不同定义限制了不同研究之间 AKI 发生率的比较。最近，大多数研究采用急性肾损伤网络（AKIN）标准来定义和分类 AKI。除了 AKIN 标准外，还使用其他分类标准，如风险、损伤、衰竭、丧失和终末期肾病（RIFLE）以及肾脏疾病：改善全球结局（KDIGO）标准来定义 AKI。值得注意的是，即使 AKI 以外的血清肌酐略有升高也可能与不良结局相关，包括住院时间延长和增加。急性肾损伤（AKI）是经皮冠状动脉介入治疗（PCI）的严重且潜在可预防的并发症。肾功能恶化与不良结局相关，包括住院死亡率增加。在因急性心肌梗死（AMI）而行直接经皮冠状动脉介入治疗的患者中，AKI 的发生率高达 20%。AKI 的不同定义限制了不同研究之间 AKI 发生率的比较。此外，即使 AKI 定义水平以外的血清肌酐略有升高也可能与不良结局相关，包括住院时间延长。
