Friedman Z, Hackett S F, Campochiaro P A
Exp Eye Res. 1987 Apr;44(4):471-9. doi: 10.1016/s0014-4835(87)80158-6.
Human retinal pigment epithelial cells in culture demonstrate adenylate cyclase activity. It is membrane-bound and modulated by GTP regulatory proteins. It is effectively activated only by beta-adrenergic agonists (L-isoproterenol greater than or equal to L-epinephrine greater than L-norepinephrine) and some prostaglandins (PGE1 and PGE2, but not PGF1 alpha). The adrenergic response appears to be mediated by beta-2 receptors. No inhibitory ligands could be demonstrated. Its characteristics, which are similar to functional adenylate cyclase complexes in other mammalian cells, and its selective and sensitive agonist responsiveness, suggest a possible physiologic role in the regulation of human retinal pigment epithelial-cell function.
培养的人视网膜色素上皮细胞表现出腺苷酸环化酶活性。它是膜结合的，并受GTP调节蛋白调控。它仅被β-肾上腺素能激动剂（L-异丙肾上腺素≥L-肾上腺素＞L-去甲肾上腺素）和一些前列腺素（PGE1和PGE2，但不是PGF1α）有效激活。肾上腺素能反应似乎由β-2受体介导。未发现抑制性配体。其特性与其他哺乳动物细胞中的功能性腺苷酸环化酶复合物相似，以及其选择性和敏感的激动剂反应性，提示其在调节人视网膜色素上皮细胞功能中可能具有生理作用。
