Modak Tamonud, Kumar Saurabh, Pal Arghya, Gupta Rishab, Pattanayak Raman Deep, Khandelwal Sudhir Kumar
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Indian J Psychol Med. 2017 Jul-Aug;39(4):539-541. doi: 10.4103/0253-7176.211759.
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3 episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed.
一名22岁被诊断为双相情感障碍的男性患者前来就诊，其经历了3次躁狂发作，对奥氮平和氟哌啶醇以及电休克治疗均无反应。然而，他对氯丙嗪（CPZ）有反应，氯丙嗪作为一种情绪稳定剂也有效。当停用氯丙嗪时患者病情复发，重新开始使用时又有反应。该病例表明氯丙嗪可能既作为一种抗躁狂药物，又在双相情感障碍的维持治疗中发挥作用。还讨论了这一作用可能的潜在机制。
