氯丙嗪用于双相情感障碍伴治疗及电休克治疗难治性躁狂的预防：老马新用
Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick.
作者信息
Modak Tamonud, Kumar Saurabh, Pal Arghya, Gupta Rishab, Pattanayak Raman Deep, Khandelwal Sudhir Kumar
机构信息
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Indian J Psychol Med. 2017 Jul-Aug;39(4):539-541. doi: 10.4103/0253-7176.211759.
Abstract
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3 episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed.
摘要
一名22岁被诊断为双相情感障碍的男性患者前来就诊，其经历了3次躁狂发作，对奥氮平和氟哌啶醇以及电休克治疗均无反应。然而，他对氯丙嗪（CPZ）有反应，氯丙嗪作为一种情绪稳定剂也有效。当停用氯丙嗪时患者病情复发，重新开始使用时又有反应。该病例表明氯丙嗪可能既作为一种抗躁狂药物，又在双相情感障碍的维持治疗中发挥作用。还讨论了这一作用可能的潜在机制。
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