Yoshioka M, Asakura H, Hamada Y, Miura S, Kobayashi K, Morishita T, Morita A, Tsuchiya M
Digestion. 1987;36(3):141-7. doi: 10.1159/000199411.
The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal cyclic AMP (cAMP) concentration were observed. The activity of alkaline phosphatase, aminopeptidase and sucrase increased in the intestinal lumen after toxin exposure. In intestinal lymph, alkaline phosphatase activity was increased after cholera toxin administration, while aminopeptidase activity remained unchanged. Somatostatin suppressed cholera toxin-induced secretory diarrhea, but it did not affect the elevated mucosal cAMP concentration. This peptide also inhibited the appearance of glycoenzymes in the intestinal lumen and lymph induced by cholera toxin administration. These results suggest that somatostatin exerts its inhibitory effects on cholera toxin-induced secretory diarrhea and on the appearance of glycoenzymes in the intestinal lumen and lymph by affecting processes beyond cAMP formation.
在大鼠小肠中研究了生长抑素对霍乱毒素诱导的分泌性腹泻以及肠腔和肠淋巴中糖酶出现的影响。暴露于霍乱毒素后，观察到小肠中有明显的液体蓄积，空肠黏膜环磷酸腺苷（cAMP）浓度升高。毒素暴露后，肠腔中碱性磷酸酶、氨肽酶和蔗糖酶的活性增加。在肠淋巴中，给予霍乱毒素后碱性磷酸酶活性增加，而氨肽酶活性保持不变。生长抑素抑制霍乱毒素诱导的分泌性腹泻，但不影响升高的黏膜cAMP浓度。这种肽还抑制了霍乱毒素给药诱导的肠腔和淋巴中糖酶的出现。这些结果表明，生长抑素通过影响cAMP形成以外的过程，对霍乱毒素诱导的分泌性腹泻以及肠腔和淋巴中糖酶的出现发挥其抑制作用。
