Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Japan.
Biomed Res Int. 2017;2017:8132676. doi: 10.1155/2017/8132676. Epub 2017 Aug 9.
Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs.
We retrospectively reviewed 27 patients with PMSTs and calculated SUV, MTV, and total lesion glycolysis (TLG) to compare their accuracy in predicting progression-free survival (PFS) and overall survival (OS) by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were used to compare the reliability of the metabolic parameters and various clinical factors.
MTV exhibited greater accuracy than SUV or TLG. The cut-off values for PFS and OS derived from the AUC data were MTV 45 ml and 83 ml and TLG 250 SUV⁎ml and 257 SUV⁎ml, respectively. MTV above cut-off value, but not TLG, was identified as significant prognostic factor for PFS by log-lank test ( = 0.04). In addition, MTV was the only significant predictive factors for PFS and OS in the multivariate analysis.
MTV was a more accurate predictor of PFS and OS in PMSTs compared to TLG or SUV and helped decision-making for guiding rational treatment options.
原发性脊柱/脊髓恶性肿瘤（PMST）是一种罕见且危及生命的疾病。在本研究中，我们展示了基于体积的 F-FDG PET/CT 代谢参数代谢肿瘤体积（MTV）在评估 PMST 侵袭性方面的优势。
我们回顾性分析了 27 例 PMST 患者，并计算了 SUV、MTV 和总病变糖酵解（TLG），通过受试者工作特征（ROC）曲线分析比较其预测无进展生存期（PFS）和总生存期（OS）的准确性。采用单因素和多因素分析比较代谢参数和各种临床因素的可靠性。
MTV 的准确性优于 SUV 或 TLG。AUC 数据得出的 PFS 和 OS 的截断值分别为 MTV45ml 和 83ml，TLG250SUV⁎ml 和 257SUV⁎ml。对数秩检验（ = 0.04）表明，MTV 高于截断值而非 TLG 是 PFS 的显著预后因素。此外，MTV 是多因素分析中 PFS 和 OS 的唯一显著预测因素。
与 TLG 或 SUV 相比，MTV 是 PMST 患者 PFS 和 OS 的更准确预测指标，有助于指导合理治疗方案的决策。
