Kozlov K L, Bolotov I I, Lin'kova N S, Drobintseva A O
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):566-569. doi: 10.1007/s10517-017-3850-7. Epub 2017 Aug 29.
We compared the expression of signal molecules in the culture of human endothelial cells under normal conditions and in atherosclerosis and restenosis. Expression of connexin-37 and sirtuin-1 in atherosclerosis and restenosis surpassed the normal by 2 and 5 times, respectively, and expression of endothelin-1 3-fold surpassed the normal. In restenosis, changes in the expression connexin-37 and endothelin-1 became more pronounced in comparison with atherosclerosis. Connexin-37 and endothelin-1 can serve as predictive markers for prognosis of post-stenting complications in patients with atherosclerosis.
