四聚体重组人丁酰胆碱酯酶作为一种生物药物用于改善急性有机磷中毒症状的应用。
Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning.
作者信息
Terekhov S S, Palikov V A, Palikova Y A, Dyachenko I A, Shamborant O G, Smirnov I V, Masson P, Gabibov A G
机构信息
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
出版信息
Bull Exp Biol Med. 2017 Aug;163(4):430-435. doi: 10.1007/s10517-017-3821-z. Epub 2017 Aug 29.
We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield >30 mg/liter (>90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
我们提出了一种优化重组四聚体丁酰胆碱酯酶表达的方法，该方法能够实现大规模生产，产量>30毫克/升（>90毫克/滚瓶）。静脉注射该制剂可显著提高对氧磷（一种有机磷毒素）中毒后的生存率并减轻中毒症状的严重程度。
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