Meneilly G S, Elahi D, Minaker K L, Rowe J W
J Clin Endocrinol Metab. 1987 Aug;65(2):364-7. doi: 10.1210/jcem-65-2-364.
We examined the effect of somatostatin (SRIH) infusion on insulin-mediated glucose disposal (Rd) in normal young subjects (n = 8) to determine the influence of SRIH on insulin action. Paired 3-h euglycemic insulin clamp studies were performed in random order employing insulin alone (25 mU/m2 X min) or insulin with SRIH (250 micrograms/h) and replacement of basal glucagon (0.4 ng/kg X min). Basal plasma glucose, insulin, glucagon (IRG), and GH concentrations, hepatic glucose production, and Rd were similar on each occasion. Steady state (10-180 min) plasma insulin insulin alone, 283 +/- 10 (+/- SEM); insulin, IRG, and SRIH, 284 +/- 10 pmol/L) and glucagon levels (insulin alone, 84 +/- 7; insulin, IRG, and SRIH, 82 +/- 7 ng/L) were similar. Hepatic glucose production (insulin alone, 0.66 +/- 0.12; insulin, IRG, and SRIH, 0.78 +/- 0.48 mg/kg X min) and Rd (insulin alone, 8.16 +/- 0.62; insulin, IRG, and SRIH, 8.17 +/- 0.61 mg/kg X min) were not different at steady state. We conclude that SRIH infusion with glucagon replacement does not augment insulin-mediated glucose disposal in normal young subjects at physiological insulin levels.
我们研究了生长抑素（SRIH）输注对正常年轻受试者（n = 8）胰岛素介导的葡萄糖处置（Rd）的影响，以确定SRIH对胰岛素作用的影响。采用单独胰岛素（25 mU/m2×min）或胰岛素联合SRIH（250微克/小时）并补充基础胰高血糖素（0.4 ng/kg×min），以随机顺序进行配对的3小时正常血糖胰岛素钳夹研究。每次基础血浆葡萄糖、胰岛素、胰高血糖素（IRG）和生长激素浓度、肝脏葡萄糖生成和Rd均相似。稳态（10 - 180分钟）时血浆胰岛素水平（单独胰岛素，283±10（±SEM）；胰岛素、IRG和SRIH，284±10 pmol/L）和胰高血糖素水平（单独胰岛素，84±7；胰岛素、IRG和SRIH，82±7 ng/L）相似。稳态时肝脏葡萄糖生成（单独胰岛素，0.66±0.12；胰岛素、IRG和SRIH，0.78±0.48 mg/kg×min）和Rd（单独胰岛素，8.16±0.62；胰岛素、IRG和SRIH，8.17±0.61 mg/kg×min）无差异。我们得出结论，在生理胰岛素水平下，输注SRIH并补充胰高血糖素不会增强正常年轻受试者胰岛素介导的葡萄糖处置。
