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[肝硬化患者的门静脉血栓形成]

[Portal vein thrombosis in patients with cirrhosis].

作者信息

Dupuis Melissa, Spahr Laurent, Giostra Emiliano, Elkrief Laure

机构信息

Service de gastroentérologie et hépatologie, Centre des affections hépatobiliaires et pancréatiques, HUG, 1211 Genève 14.

Service de transplantation, HUG, 1211 Genève 14.

出版信息

Rev Med Suisse. 2017 Aug 30;13(572):1470-1473.

Abstract

Portal vein thrombosis is frequently encountered in patients with cirrhosis. Increased indication for non-invasive imaging in patients with cirrhosis has dramatically increased the recognition of PVT. This has led to a large amount of studies on pathogenesis as well as the prognostic impact of portal vein thrombosis on natural history of cirrhosis. However, in clinical practice, several aspects of the management of portal vein thrombosis remain unclear. This practical review discusses the most recent data toward the management of portal vein thrombosis in cirrhosis, especially regarding : a) the value of etiological workup ; b) the impact of portal vein thrombosis on the natural history of cirrhosis, and c) the indications and modalities of anticoagulation therapy.

摘要

门静脉血栓形成在肝硬化患者中很常见。肝硬化患者非侵入性成像检查指征的增加显著提高了对门静脉血栓形成的认识。这引发了大量关于发病机制以及门静脉血栓形成对肝硬化自然病程预后影响的研究。然而,在临床实践中,门静脉血栓形成的管理在几个方面仍不明确。本实用综述讨论了肝硬化门静脉血栓形成管理的最新数据,特别是关于:a)病因检查的价值;b)门静脉血栓形成对肝硬化自然病程的影响,以及c)抗凝治疗的指征和方式。

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