García Alonso L, Pumarada Prieto M, González Colmenero E, Concheiro Guisán A, Suárez Albo M, Durán Fernández-Feijoo C, González Durán L, Fernández Lorenzo J R
Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain.
Am J Perinatol. 2018 Jan;35(2):170-176. doi: 10.1055/s-0037-1606358. Epub 2017 Aug 30.
Antenatal magnesium sulfate (MgSO) administration has shown to be effective in minimizing cerebral palsy and severe motor dysfunction at the age of 2 years. The aim of this study is to determine the relationship between the magnesium dose delivered to the mother and the magnesium concentration in the neonates.
A prospective cohort study was conducted on neonates of less than 32 weeks' gestation admitted to the neonatal intensive care unit of University Hospital Complex of Vigo from December 2012 to July 2015. Comparative analysis of magnesium levels between the groups of neonates exposed to MgSO and the control group.
A total of 118 neonates were included in the study. The mothers of 62 of them had received MgSO as a neuroprotective agent. There was a significant correlation between the full dose of MgSO received by the mother and the levels of magnesium in the neonate in the first 24 hours of life ( = 0.397; < 0.001).
The MgSO dose received by the mother has a linear relationship with the magnesium levels obtained in neonates.
产前使用硫酸镁（MgSO）已被证明在降低2岁时脑瘫和严重运动功能障碍的发生率方面是有效的。本研究的目的是确定给予母亲的镁剂量与新生儿体内镁浓度之间的关系。
对2012年12月至2015年7月入住维戈大学医院综合新生儿重症监护病房的孕周小于32周的新生儿进行了一项前瞻性队列研究。对暴露于硫酸镁的新生儿组和对照组的镁水平进行比较分析。
本研究共纳入118例新生儿。其中62例新生儿的母亲接受了硫酸镁作为神经保护剂。母亲接受的硫酸镁全剂量与新生儿出生后24小时内的镁水平之间存在显著相关性（r = 0.397；P < 0.001）。
母亲接受的硫酸镁剂量与新生儿体内获得的镁水平呈线性关系。
