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MSDB:简单序列重复序列综合数据库。

MSDB: A Comprehensive Database of Simple Sequence Repeats.

作者信息

Avvaru Akshay Kumar, Saxena Saketh, Sowpati Divya Tej, Mishra Rakesh Kumar

机构信息

CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India.

出版信息

Genome Biol Evol. 2017 Jun 1;9(6):1797-1802. doi: 10.1093/gbe/evx132.

Abstract

Microsatellites, also known as Simple Sequence Repeats (SSRs), are short tandem repeats of 1-6 nt motifs present in all genomes, particularly eukaryotes. Besides their usefulness as genome markers, SSRs have been shown to perform important regulatory functions, and variations in their length at coding regions are linked to several disorders in humans. Microsatellites show a taxon-specific enrichment in eukaryotic genomes, and some may be functional. MSDB (Microsatellite Database) is a collection of >650 million SSRs from 6,893 species including Bacteria, Archaea, Fungi, Plants, and Animals. This database is by far the most exhaustive resource to access and analyze SSR data of multiple species. In addition to exploring data in a customizable tabular format, users can view and compare the data of multiple species simultaneously using our interactive plotting system. MSDB is developed using the Django framework and MySQL. It is freely available at http://tdb.ccmb.res.in/msdb.

摘要

微卫星,也称为简单序列重复(SSR),是存在于所有基因组中,尤其是真核生物基因组中的1 - 6个核苷酸基序的短串联重复序列。除了作为基因组标记有用之外,微卫星已被证明具有重要的调控功能,并且它们在编码区的长度变化与人类的几种疾病有关。微卫星在真核生物基因组中表现出特定分类群的富集,有些可能具有功能。MSDB(微卫星数据库)是一个包含来自6893个物种(包括细菌、古细菌、真菌、植物和动物)的超过6.5亿个SSR的集合。该数据库是目前获取和分析多个物种SSR数据的最详尽资源。除了以可定制的表格格式探索数据外,用户还可以使用我们的交互式绘图系统同时查看和比较多个物种的数据。MSDB是使用Django框架和MySQL开发的。可在http://tdb.ccmb.res.in/msdb免费获取。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd62/5533116/61ae34b2b994/evx132f1.jpg

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