Moris Demetrios, Damaskos Christos, Davakis Spyridon, Vailas Michail, Garmpis Nikolaos, Spartalis Eleftherios, Kontos Michael, Kontzoglou Konstantinos
Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Ann Transl Med. 2017 Aug;5(15):309. doi: 10.21037/atm.2017.05.24.
Idiopathic granulomatous mastitis (IGM), is a rare entity of chronic inflammatory disorder of the breast of unknown etiology. Very few cases have been described so far, almost exclusively in women. Here we describe a case of IGM in a 53-year-old man presented with a right breast mass, progressively enlarging during the last 6 months. Due to the findings of clinical examination and CT-scan, the suspicion for a potentially malignant lesion was given and the decision for surgical resection was made. Microscopic analysis of the specimen showed non-caseating granulomas around mammary lobules, findings compatible with IGM. The patient is recurrence-free at 18-month follow-up. IGM is a rare benign inflammatory breast disease, usually seen in females of reproductive age. Establishing a diagnosis can be challenging for a surgeon and requires a high index of suspicion as most patients are initially misdiagnosed by their primary care physicians. Steroids and immunosuppressive drugs are considered as fundamental treatment modalities but they are correlated with increased rates of disease response and recurrence. On the contrary, surgical resection demonstrated significantly superior results compared to steroid-alone treatment in terms of recurrence and post-treatment recovery.
特发性肉芽肿性乳腺炎（IGM）是一种病因不明的罕见的乳腺慢性炎症性疾病。迄今为止，仅有极少数病例被报道，几乎均为女性患者。在此，我们报告一例53岁男性的IGM病例，该患者以右乳肿块就诊，在过去6个月中肿块逐渐增大。基于临床检查和CT扫描结果，怀疑为潜在恶性病变，并决定进行手术切除。标本的显微镜分析显示乳腺小叶周围有非干酪样肉芽肿，这些发现与IGM相符。在18个月的随访中，该患者无复发。IGM是一种罕见的良性炎性乳腺疾病，通常见于育龄女性。对于外科医生而言，做出诊断可能具有挑战性，并且需要高度的怀疑指数，因为大多数患者最初会被初级保健医生误诊。类固醇和免疫抑制药物被视为基本的治疗方式，但它们与疾病缓解率和复发率的增加相关。相反，在复发率和治疗后恢复方面，手术切除显示出比单纯使用类固醇治疗明显更好的效果。
