Åkerstedt Torbjörn, Ghilotti Francesca, Grotta Alessandra, Bellavia Andrea, Lagerros Ylva Trolle, Bellocco Rino
Department of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
Eur J Epidemiol. 2017 Oct;32(10):881-891. doi: 10.1007/s10654-017-0297-0. Epub 2017 Aug 30.
Prior work has shown that both short and long sleep predict mortality. However, sleep duration decreases with age and this may affect the relationship of sleep duration with mortality. The purpose of the present study was to assess whether the association between sleep duration and mortality varies with age. Prospective cohort study. 43,863 individuals (64% women), recruited in September 1997 during the Swedish National March and followed through record-linkages for 13 years. Sleep duration was self-reported and measured using the Karolinska Sleep Questionnaire, and grouped into 4 categories: ≤5, 6, 7 (reference) and ≥8 h. Up to 2010 3548 deaths occurred. Multivariable Cox proportional hazards regression models with attained age as time scale were fitted to estimate mortality rate ratios. Among individuals <65 years, short (≤5 h) and long (≥8 h) sleep duration showed a significant relationship with mortality (HR 1.37, 95% CI 1.09-1.71, and HR 1.27, 95% CI 1.08-1.48). Among individuals 65 years or older, no relationships between sleep duration and mortality were observed. The effect of short and long sleep duration on mortality was highest among young individuals and decreased with increasing age. The results suggest that age plays an important role in the relationship between sleep duration and mortality.
先前的研究表明,睡眠时间过短和过长都预示着死亡风险。然而,睡眠时间会随着年龄的增长而减少,这可能会影响睡眠时间与死亡率之间的关系。本研究的目的是评估睡眠时间与死亡率之间的关联是否会随年龄而变化。前瞻性队列研究。1997年9月在瑞典全国范围内招募了43863名个体(64%为女性),通过记录链接对其进行了13年的跟踪调查。睡眠时间通过卡罗林斯卡睡眠问卷进行自我报告和测量,并分为4类:≤5小时、6小时、7小时(参照组)和≥8小时。截至2010年,共发生3548例死亡。采用以达到年龄为时间尺度的多变量Cox比例风险回归模型来估计死亡率比值。在65岁以下的个体中,睡眠时间过短(≤5小时)和过长(≥8小时)与死亡率存在显著关联(风险比1.37,95%置信区间1.09 - 1.71;风险比1.27,95%置信区间1.08 - 1.48)。在65岁及以上的个体中,未观察到睡眠时间与死亡率之间的关联。睡眠时间过短和过长对死亡率的影响在年轻人中最高,并随着年龄的增长而降低。研究结果表明,年龄在睡眠时间与死亡率之间的关系中起着重要作用。