剖宫产术中昂丹司琼用于脊髓麻醉的疗效：随机试验的荟萃分析
Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials.
作者信息
Zhou Chengmao, Zhu Yu, Bao Zeqing, Wang Xianxue, Liu Qili
机构信息
1 117835 Zhaoqing Medical College , Zhaoqing, China.
2 Department of Anesthesiology, The First People's Hospital of Changde, Changde, China.
出版信息
J Int Med Res. 2018 Feb;46(2):654-662. doi: 10.1177/0300060517716502. Epub 2017 Aug 31.
Objective To investigate the efficacy and safety of ondansetron during cesarean section under spinal anesthesia. Methods We sought randomized controlled trials (RCTs) on ondansetron during spinal anesthesia for cesarean section in The Cochrane Library, PubMed, MEDLINE, and Web of Science from their inception to September 2016. Results Altogether, 21 RCTs were included in this study. Meta-analysis showed that the ondansetron group had a lower incidence of nausea/vomiting and bradycardia than the placebo group during cesarean section under spinal anesthesia [relative risk (RR) = 0.43, 95% confidence interval (CI) (0.36, 0.51) and RR = 0.45, 95% CI (0.26, 0.80), respectively]. There were no significant differences in the incidences of pruritus, hypotension, or shivering during cesarean section under spinal anesthesia [RR = 0.92, 95% CI (0.83, 1.02); RR = 0.72 (0.50, 1.06), 95% CI (0.50, 1.06); and RR = 0.89, 95% CI (0.71, 1.11), respectively]. Conclusion Ondansetron effectively reduces the incidences of nausea/vomiting and bradycardia under spinal anesthesia during cesarean section.
目的 探讨昂丹司琼在腰麻剖宫产术中的有效性和安全性。方法 检索Cochrane图书馆、PubMed、MEDLINE和Web of Science数据库，纳入自建库起至2016年9月期间关于腰麻剖宫产术中使用昂丹司琼的随机对照试验（RCT）。结果 本研究共纳入21项RCT。荟萃分析显示，在腰麻剖宫产术中，昂丹司琼组恶心/呕吐和心动过缓的发生率低于安慰剂组[相对危险度（RR）分别为0.43，95%置信区间（CI）为（0.36，0.51）；RR为0.45，95%CI为（0.26，0.80）]。腰麻剖宫产术中瘙痒、低血压或寒战的发生率无显著差异[RR分别为0.92，95%CI为（0.83，1.02）；RR为0.72（0.50，1.06），95%CI为（0.50，1.06）；RR为0.89，95%CI为（0.71，1.11）]。结论 昂丹司琼可有效降低腰麻剖宫产术中恶心/呕吐和心动过缓的发生率。
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