鞘内注射右美托咪定对脊髓麻醉下剖宫产的影响：一项随机试验的荟萃分析

Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials.

作者信息

Wang Yun-Qi, Zhang Xian-Jie, Wang Ying

机构信息

Department of Anesthesiology, People's Hospital of Deyang City, Sichuan, People's Republic of China.

Department of Anesthesiology, The Sixth People's Hospital of Deyang City, Sichuan, People's Republic of China.

出版信息

Drug Des Devel Ther. 2019 Aug 21;13:2933-2939. doi: 10.2147/DDDT.S207812. eCollection 2019.

OBJECTIVE

Intrathecal dexmedetomidine has been used in spinal anesthesia during cesarean sections. The purpose of this meta-analysis was to investigate the effect of intrathecal dexmedetomidine on the adverse reactions of spinal anesthesia during cesarean section.

METHODS

We searched for relevant studies using PubMed, Web of Science, and the Cochrane library. After screening studies and extracting data, we performed a meta-analysis on the effect of intrathecal dexmedetomidine during cesarean section.

RESULTS

A total of 278 patients from 4 studies were included in this meta-analysis. The incidence of shivering in the dexmedetomidine groups was significantly lower than that in the placebo groups during cesarean section (RR=0.40, 95% CI [0.25, 0.65], =0.0002). Intrathecal dexmedetomidine had no effect on nausea and vomiting (RR=1.08, 95% CI [0.68, 1.71], =0.74), bradycardia (RR=1.33, 95% CI [0.31, 5.76], =0.70), and hypotension during cesarean section (RR=0.78, 95% CI [0.59, 1.03], =0.08).

CONCLUSION

Intrathecal dexmedetomidine can effectively reduce the occurrence of shivering during cesarean section, but it does not affect the occurrence of nausea and vomiting, bradycardia or hypotension.

目的

鞘内注射右美托咪定已用于剖宫产术中的脊髓麻醉。本荟萃分析的目的是研究鞘内注射右美托咪定对剖宫产术中脊髓麻醉不良反应的影响。

方法

我们使用PubMed、科学网和考克兰图书馆检索相关研究。在筛选研究和提取数据后，我们对剖宫产术中鞘内注射右美托咪定的效果进行了荟萃分析。

结果

本荟萃分析共纳入4项研究中的278例患者。剖宫产术中右美托咪定组的寒战发生率显著低于安慰剂组（RR=0.40，95%CI[0.25，0.65]，P=0.0002）。鞘内注射右美托咪定对剖宫产术中恶心呕吐（RR=1.08，95%CI[0.68，1.71]，P=0.74）、心动过缓（RR=1.33，95%CI[0.31，5.76]，P=0.70）和低血压（RR=0.78，95%CI[0.59，1.03]，P=0.08）无影响。