下丘脑腹内侧刺激可加速大鼠棕色脂肪组织中去甲肾上腺素的更新。

Ventromedial hypothalamic stimulation accelerates norepinephrine turnover in brown adipose tissue of rats.

作者信息

Saito M, Minokoshi Y, Shimazu T

出版信息

Life Sci. 1987 Jul 13;41(2):193-7. doi: 10.1016/0024-3205(87)90493-0.

Abstract

To establish a functional link between the ventromedial hypothalamus (VMH) and brown adipose tissue (BAT), effects of electrical stimulation of the VMH and the lateral hypothalamus (LH) on norepinephrine (NE) turnover in the interscapular BAT were examined in rats. Stimulation of the VMH elicited about 3-fold increase in the rate of NE turnover in BAT, whereas stimulation of the LH had no appreciable effects. The effect of VMH stimulation was abolished after sympathetic ganglion blockade or by surgical sympathetic denervation of BAT. It was concluded that there is a sympathetic nerve-mediated connection between the VMH and BAT, and that stimulation of the VMH induces metabolic activation and heat production in BAT through an increase in sympathetic nerve activity.

摘要

为了建立腹内侧下丘脑（VMH）与棕色脂肪组织（BAT）之间的功能联系，研究了电刺激大鼠VMH和外侧下丘脑（LH）对肩胛间BAT中去甲肾上腺素（NE）周转的影响。刺激VMH可使BAT中NE周转速率增加约3倍，而刺激LH则无明显影响。在交感神经节阻断后或通过对BAT进行手术性交感神经去支配后，VMH刺激的作用消失。得出的结论是，VMH和BAT之间存在交感神经介导的联系，并且刺激VMH通过增加交感神经活动诱导BAT中的代谢激活和产热。