Al-Younes Hesham M, Al-Zereini Wael, Obeidat Nathir M
Department of Biological Sciences, Faculty of Science, the University of Jordan, Amman 11942, Jordan.
Department of Biological Sciences, Faculty of Science, Mutah University, Al-Karak, Jordan.
J Med Microbiol. 2017 Sep;66(9):1324-1327. doi: 10.1099/jmm.0.000564. Epub 2017 Aug 31.
Simkania negevensis has been implicated in respiratory diseases. This study aimed to unveil the aetiological role of this bacterium in community-acquired pneumonia (CAP) and bronchitis in Jordanian adults. Nasopharyngeal samples were collected from 98 CAP or bronchitis patients and 96 control individuals, and tested for Simkania nucleic acids using a PCR assay. The overall prevalence of the bacterial DNA in patients was markedly high and reached 57.1 %. Intriguingly, Simkania DNA was detected in 62.5 % of the nasopharyngeal swabs collected from apparently healthy controls (P>0.05). The DNA positivity in the bronchitis and CAP subgroups was 57.7 and 56.9 %, respectively, percentages that are approximately comparable to the DNA positivity assessed for the entire patient population. Simkania is most likely not a causative agent of CAP or bronchitis, despite its remarkable high prevalence. This organism, in the nasopharynx, is potentially harmless to the host and may coexist in a commensal relationship.
西曼凯尼亚内格维西菌与呼吸道疾病有关。本研究旨在揭示该细菌在约旦成年人社区获得性肺炎（CAP）和支气管炎中的病因学作用。从98例CAP或支气管炎患者和96例对照个体中采集鼻咽样本，使用聚合酶链反应（PCR）检测法检测西曼凯尼亚核酸。患者中细菌DNA的总体患病率明显很高，达到57.1%。有趣的是，在从看似健康的对照个体中采集的62.5%的鼻咽拭子中检测到了西曼凯尼亚DNA（P>0.05）。支气管炎和CAP亚组中的DNA阳性率分别为57.7%和56.9%，这两个百分比与对整个患者群体评估的DNA阳性率大致相当。尽管西曼凯尼亚患病率极高，但它很可能不是CAP或支气管炎的病原体。这种生物体在鼻咽部对宿主可能无害，可能以共生关系共存。
