Sobeih Doaa H, Cotran Paul R
*Department of Ophthalmology, Lahey Hospital and Medical Center, Burlington, MA †Matrouh Hospital, Marsa Matrouh, Egypt.
J Glaucoma. 2017 Oct;26(10):947-953. doi: 10.1097/IJG.0000000000000770.
To evaluate outcomes after revision of failed fornix-based trabeculectomy using a posterior conjunctival incision and mitomycin C.
Cases were identified using Current Procedural Terminology codes. Information from clinical records was analyzed retrospectively. Complete success was defined as intraocular pressure (IOP) ≤16 mm Hg with no glaucoma medications and IOP reduction of >20% from preoperative levels. Qualified success was defined as IOP≤16 with or without medications and IOP reduction of >20%. Secondary outcomes included IOP, number of glaucoma medications used, visual acuity, and complications.
Sixty eyes of 56 patients underwent surgical revision of failed trabeculectomy. The complete success rate at 1 year was 43.7%, declining to 41.7% at 2 years and all time points up to 5 years; qualified success rates were 68.9% at 1 year and at all subsequent time points. Mean IOP declined from 21.2±7.7 (SD) mm Hg preoperatively to 10.9±4.3 mm Hg at 1 year, to 10.5±3.8 mm Hg at 2 years, and to 9.9±4.6 mm Hg at 3 years. The mean number of glaucoma medications used fell from 2.5±0.5 preoperatively to 1.0±0.4 at 1 year, 0.9±0.4 at 2 years, and 0.9±0.4 at 3 years. Complications included bleb leak in 3 eyes (5.0%), hypotony with choroidal detachment in 3 eyes (5.0%) and hyphema in 1 eye (1.7%). Eight eyes required additional glaucoma surgery.
Surgical bleb revision with mitomycin C using a posterior incision in cases of failed fornix-based trabeculectomy can provide effective control of IOP. This conjunctiva-sparing procedure should be considered as a viable alternative to a tube shunt or repeat trabeculectomy.
评估采用结膜后切口联合丝裂霉素C对失败的穹窿部小梁切除术进行翻修后的效果。
使用当前手术操作术语编码识别病例。对临床记录中的信息进行回顾性分析。完全成功定义为眼压(IOP)≤16 mmHg且无需使用青光眼药物,眼压较术前水平降低>20%。合格成功定义为眼压≤16 mmHg(无论是否使用药物)且眼压降低>20%。次要结局包括眼压、使用的青光眼药物数量、视力和并发症。
56例患者的60只眼接受了失败小梁切除术的手术翻修。1年时的完全成功率为43.7%,2年时降至41.7%,直至5年的所有时间点均如此;合格成功率在1年及随后所有时间点均为68.9%。平均眼压从术前的21.2±7.7(标准差)mmHg降至1年时的10.9±4.3 mmHg,2年时降至10.5±3.8 mmHg,3年时降至9.9±4.6 mmHg。使用的青光眼药物平均数量从术前的2.5±0.5降至1年时的1.0±0.4,2年时为0.9±0.4,3年时为0.9±0.4。并发症包括3只眼(5.0%)出现滤过泡渗漏,3只眼(5.0%)出现低眼压伴脉络膜脱离,1只眼(1.7%)出现前房积血。8只眼需要额外的青光眼手术。
对于失败的穹窿部小梁切除术,采用结膜后切口联合丝裂霉素C进行手术性滤过泡翻修可有效控制眼压。这种保留结膜的手术应被视为管状分流术或重复小梁切除术的可行替代方案。