Depresseux J C, Franck G, Van Cauwenberge H
Presse Med. 1987 Jun 18;16(23):1145-50.
Positron emission tomography and oxygen-15 were used to evaluate the effects of an almitrine-raubasine combination on cerebral blood flow and oxydation metabolism in patients with acute cerebral ischaemia. In 5 patients, aged between 58 and 74 years, with cerebral ischaemic accident in the territory of the middle cerebral artery, blood flow rate, oxygen consumption and brain oxygen extraction were measured before and after a 90-min intravenous infusion of almitrine bismesilate 15 mg and raubasine 5 mg. Only one patient presented with initial relative luxury perfusion, the intensity of which was reduced by the combined treatment. The other 4 patients had focal reduction of cerebral blood flow and oxygen consumption prior to treatment. Statistical analysis conducted on three cerebral areas (epicentre of the lesion, anterior and posterior juxtalesional areas and homologous heterolateral areas) showed a significant 3.6% increase of oxygen consumption in the epicentre, both hemispheres included, and a significant increase of cerebral blood flow in all three areas (3% on the healthy side, 13% on the diseased side). No significant change in oxygen extraction was demonstrated. The authors conclude that acute almitrine-raubasine treatment has beneficial effects on the brain immediately after a cerebral vascular accident, reflecting respect of the circulation-metabolism couple.
采用正电子发射断层扫描术和氧 - 15来评估阿米三嗪 - 萝巴新组合对急性脑缺血患者脑血流量和氧化代谢的影响。对5例年龄在58至74岁之间、大脑中动脉供血区域发生脑缺血性意外的患者，在静脉输注15毫克双甲磺酸阿米三嗪和5毫克萝巴新90分钟前后，测量其血流速度、氧耗量和脑氧摄取率。只有1例患者最初表现为相对的过度灌注，联合治疗后其强度降低。其他4例患者在治疗前脑血流量和氧耗量呈局灶性降低。对三个脑区（病变中心、病变前后毗邻区域和同侧异侧同源区域）进行的统计分析显示，包括双侧半球在内的病变中心氧耗量显著增加3.6%，所有三个区域的脑血流量均显著增加（健康侧增加3%，患侧增加13%）。未显示氧摄取率有显著变化。作者得出结论，急性阿米三嗪 - 萝巴新治疗在脑血管意外后即刻对大脑有有益作用，这反映了对循环 - 代谢耦合关系的维持。
