中枢神经系统血管中的配体选择性 Wnt 受体复合物：RECK 和 GPR124 介入其中。
Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In.
机构信息
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
出版信息
Neuron. 2017 Aug 30;95(5):983-985. doi: 10.1016/j.neuron.2017.08.026.
PMID:28858624
Abstract
CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes.
摘要
CNS 血管生成和血脑屏障完整性受经典 Wnt 通路调控。在本期《神经元》杂志中，Cho 等人（2017）利用先进的小鼠遗传学和生化实验，揭示了膜蛋白 GPR124 和 RECK 与 Wnt 受体复合物的配体特异性关联。
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