Robinson Katie N, Vazquez-Vidal Itzel, Marques Courtney, Andrade Flavia Cristina Drumond, Aradillas-Garcia Celia, Teran-Garcia Margarita
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
J Nutrigenet Nutrigenomics. 2017;10(3-4):75-83. doi: 10.1159/000478657. Epub 2017 Aug 31.
Circulating fetuin-A (FetA) inhibits insulin receptor signaling and activates the toll-like receptor 4 proinflammatory cascade; thus, it may contribute to metabolic syndrome. Polymorphisms in alpha-2-Heremans-Schmid glycoprotein (AHSG), the gene which codes FetA, may influence metabolic syndrome progression in higher-risk ethnic groups. We aimed to identify whether individual variation in AHSG influences biomarkers of metabolic disease and obesity in young Mexican adults.
The participants were Mexican college applicants (18-25 years, n = 641). Dietary intake, anthropometric data, and blood for the analysis of biomarkers and genetics were collected. Single nucleotide polymorphisms (SNPs) in AHSG (rs2518136 and rs4917) were genotyped.
Neither AHSG SNP was associated with body mass index (BMI) or waist circumference. rs4917 C allele carriers had lower triglycerides (TG) than T allele homozygotes (98.85 ± 2.3 vs. 112.2 ± 5.2 mg/dL, p = 0.0113). BMI was strongly associated with TG (p < 0.0001) regardless of genotype. The relationship between circulating TG and dietary intake of carbohydrates and saturated fat was significant in rs4917 CT allele heterozygotes only (p = 0.03 and p = 0.02, respectively).
rs4917 T allele carriers had higher TG. This relationship was exaggerated in individuals with overweight and obesity. Dietary intake was significantly associated with TG in only those with heterozygosity at rs4917, suggesting that these individuals may be more susceptible to dietary interventions.
循环中的胎球蛋白-A（FetA）可抑制胰岛素受体信号传导并激活Toll样受体4促炎级联反应；因此，它可能与代谢综合征有关。编码FetA的基因α-2-赫曼斯-施密德糖蛋白（AHSG）的多态性可能会影响高危种族群体中代谢综合征的进展。我们旨在确定AHSG的个体差异是否会影响墨西哥年轻成年人代谢疾病和肥胖的生物标志物。
参与者为墨西哥大学申请者（18 - 25岁，n = 641）。收集饮食摄入量、人体测量数据以及用于生物标志物和遗传学分析的血液样本。对AHSG中的单核苷酸多态性（SNP，rs2518136和rs4917）进行基因分型。
两个AHSG SNP均与体重指数（BMI）或腰围无关。rs4917 C等位基因携带者的甘油三酯（TG）低于T等位基因纯合子（98.85±2.3对112.2±5.2 mg/dL，p = 0.0113）。无论基因型如何，BMI与TG均密切相关（p < 0.0001）。仅在rs4917 CT等位基因杂合子中，循环TG与碳水化合物和饱和脂肪的饮食摄入量之间的关系显著（分别为p = 0.03和p = 0.02）。
rs4917 T等位基因携带者的TG较高。这种关系在超重和肥胖个体中更为明显。仅rs4917杂合个体的饮食摄入量与TG显著相关，这表明这些个体可能对饮食干预更敏感。
