Cole Natasha Chong, Wang Anthony A, Donovan Sharon M, Lee Soo-Yeun, Teran-Garcia Margarita
Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA.
J Nutrigenet Nutrigenomics. 2017;10(3-4):84-92. doi: 10.1159/000478857. Epub 2017 Aug 31.
BACKGROUND/AIMS: Picky eating is prevalent among preschoolers and is associated with risk of both underweight and overweight. Although differences in taste perception may be due to genetic variation, it is unclear whether these variations are related to picky eating behavior. The aim of this study was to investigate the association of 6 single nucleotide polymorphisms (SNPs) in 5 candidate genes related to chemosensory perception with picky eating behavior and adiposity in a cohort of preschool-aged children.
Parents of 2- to 5-year-old non-Hispanic white preschoolers (n = 153) responded to survey questions on demographics, and information regarding their child's breastfeeding history and picky eating behavior. Height and weight were measured to calculate body mass index (BMI) z-scores using standard growth charts, and saliva was collected for genotyping. Generalized linear models were used to examine associations between picky eating behavior and BMI z-scores with genetic variation.
When controlling for child age, sex, breastfed status, and parent education level, SNPs in TAS2R38 (rs713598) and CA6 (rs2274327) were associated with picky eating behavior in children. There was no association between SNPs and BMI z-scores.
Genes related to chemosensory perception may play a role in children's picky eating behavior.
背景/目的：挑食在学龄前儿童中很普遍，与体重过轻和超重的风险都有关。尽管味觉感知的差异可能归因于基因变异，但尚不清楚这些变异是否与挑食行为有关。本研究的目的是在一组学龄前儿童中调查与化学感觉相关的5个候选基因中的6个单核苷酸多态性（SNP）与挑食行为和肥胖的关联。
2至5岁非西班牙裔白人学龄前儿童（n = 153）的父母回答了关于人口统计学的调查问题，以及有关其孩子母乳喂养史和挑食行为的信息。测量身高和体重，使用标准生长图表计算体重指数（BMI）z评分，并收集唾液进行基因分型。使用广义线性模型来检验挑食行为和BMI z评分与基因变异之间的关联。
在控制儿童年龄、性别、母乳喂养状况和父母教育水平后，TAS2R38（rs713598）和CA6（rs2274327）中的SNP与儿童的挑食行为有关。SNP与BMI z评分之间没有关联。
与化学感觉相关的基因可能在儿童挑食行为中起作用。
