Song Yang, Yang Jian Ming
Department of Otorhinolaryngology, The Second Hospital of Anhui Medical University, Hefei, 230601, PR China.
Department of Otorhinolaryngology, The Second Hospital of Anhui Medical University, Hefei, 230601, PR China.
Biochem Biophys Res Commun. 2017 Nov 4;493(1):1-8. doi: 10.1016/j.bbrc.2017.08.109. Epub 2017 Aug 30.
Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, is reported to be significantly generated by a distinct subset of CD4 T-cells, upgrading cancer-elicited inflammation and preventing cancer cells from immune surveillance. T-helper (Th)17 cells produced from naive CD4 T cells have recently been renowned and generally accepted, gaining eminence in cancer studies and playing the effective role in context of cancer. Th17 cells are the main source of IL-17-secreting cells, It was found that other cell types produced this cytokine as well, including Group 3 innate lymphoid cells (ILC3), δγT cells, invariant natural killer T (iNKT) cells, lymphoid-tissue inducer (LTi)-like cells and Natural killer (NK) cells. Th17-associated cytokines give impetus to tumor progression, or inducing angiogenesis and metastasis. This review demonstrates an understanding on how the pro- or antitumor function of Th17 cells and IL-17 may change cancer progression, leading to the appearance of complex and pivotal biologic activities in tumor.
白细胞介素-17（IL-17）是一种多效性促炎细胞因子，据报道，它由特定的CD4 T细胞亚群大量产生，会加剧癌症引发的炎症反应，并使癌细胞免受免疫监视。最近，由初始CD4 T细胞产生的辅助性T细胞（Th）17受到关注并被广泛认可，在癌症研究中地位突出，在癌症背景下发挥着重要作用。Th17细胞是分泌IL-17细胞的主要来源，研究发现其他细胞类型也能产生这种细胞因子，包括3型固有淋巴细胞（ILC3）、δγT细胞、不变自然杀伤T（iNKT）细胞、类淋巴组织诱导细胞（LTi）和自然杀伤（NK）细胞。与Th17相关的细胞因子会推动肿瘤进展，或诱导血管生成和转移。这篇综述阐述了对Th17细胞和IL-17的促肿瘤或抗肿瘤功能如何改变癌症进展的理解，这导致肿瘤中出现复杂且关键的生物学活性。
