Gaskell Christine, MacDonald Ross, Aleem Eiman, Bendriss Ghizlane
Weill Cornell Medicine Qatar, Doha, Qatar.
Cancer, Infection and Therapeutics Research Group, School of Applied and Health Sciences, College of Health and Life Sciences, London South Bank University, London, United Kingdom.
Front Nutr. 2025 Jun 9;12:1602603. doi: 10.3389/fnut.2025.1602603. eCollection 2025.
Obesity has been implicated as the driving force of many diseases including cancer through multiple biological mechanisms, including gut microbial imbalances, compromised intestinal barrier integrity, persistent low-grade inflammation, and alterations in energy uptake. As lifestyle factors such as diet, physical activity, and sleep are known to influence disease susceptibility, understanding the role of the gut microbiome in these interactions is critical. A deeper understanding of the intricate connections between gut microbiota, obesity, and various cancers could be used to better inform effective strategies for disease prevention and treatment. Investigating the microbiome's influence on tumor progression and systemic metabolic health may be the way forward for novel diagnostic and therapeutic approaches. It is essential to investigate how lifestyle factors are linked to both obesity and cancer, and what role the microbiome is playing. This review synthesizes current research on the mechanistic role of the gut microbiome in obesity and cancer, highlighting its potential role in early detection, prognosis, and its use as a targeted intervention to restore gut eubiosis.
肥胖已被认为是包括癌症在内的多种疾病的驱动因素，其通过多种生物学机制实现，包括肠道微生物失衡、肠道屏障完整性受损、持续性低度炎症以及能量摄取改变。由于饮食、体育活动和睡眠等生活方式因素已知会影响疾病易感性，因此了解肠道微生物群在这些相互作用中的作用至关重要。深入了解肠道微生物群、肥胖与各种癌症之间的复杂联系，可用于更好地为疾病预防和治疗的有效策略提供信息。研究微生物群对肿瘤进展和全身代谢健康的影响可能是新型诊断和治疗方法的前进方向。研究生活方式因素如何与肥胖和癌症相关联，以及微生物群在其中发挥何种作用至关重要。本综述综合了当前关于肠道微生物群在肥胖和癌症中机制作用的研究，强调了其在早期检测、预后中的潜在作用，以及作为恢复肠道微生态平衡的靶向干预措施的用途。
