Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, VIC 3004, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, VIC 3004, Australia; Intensive Care Unit, Austin Hospital, Studley Road Heidelberg, Victoria, 3084 Australia.
Resuscitation. 2017 Dec;121:172-178. doi: 10.1016/j.resuscitation.2017.08.240. Epub 2017 Aug 30.
To examine whether introducing a national standard to improve the recognition of and response to clinical deterioration, was associated with a reduction in cardiovascular events in the hospital environment.
Interrupted time series was used to analyse the trajectories of monthly complication rates for 4.69 million admissions in 218 hospitals. Trajectory slopes determined for the "baseline period" (1 July 2007-30 June 2010) and the "Intervention period" (1 January 2013-30 June 2014) were compared (slope ratio).
Before the intervention, complication rates due to arrhythmias were increasing, acute coronary syndrome (ACS) and all-cause mortality decreasing, but were constant for cardiac arrest and heart failure and pulmonary oedema. Analysis of the overall data suggested reduction in the rate of cardiac and ACS complications after the intervention, but no significant change in overall hospital mortality. Analysis by age category showed significant reductions in monthly rate trajectories in the 80 plus years age group for cardiac arrest (slope ratio 0.983, 95% CI: 0.972-0.994) and ACS (0.989, 95% CI: 0.981-0.997) complications. Slope ratios indicating reduced monthly rates were seen in females for cardiac arrest (0.985, 95% CI: 0.977-0.994), ACS (0.991, 95% CI: 0.984-0.998) and heart failure (0.993, 95% CI: 0.986-1.000) complications. There were also significant reductions in cardiac arrest (0.983, 95% CI: 0.969-0.996), ACS (0.991, 95% CI: 0.982-1.000) and arrhythmia (0.996, 95% CI: 0.994-0.998) complications for surgical patients.
Introduction of a national standard for deteriorating hospitalised patients was associated with a reduction in the rates of in-hospital cardiac arrests and acute coronary syndromes in acute hospitals. Greatest benefit was seen in the elderly, female and surgical patients.
探讨引入国家标准以提高对临床恶化的识别和反应能力,是否与减少医院环境中的心血管事件有关。
采用截断时间序列分析了 218 家医院 469 万例住院患者的每月并发症发生率的轨迹。比较了“基线期”(2007 年 7 月 1 日至 2010 年 6 月 30 日)和“干预期”(2013 年 1 月 1 日至 2014 年 6 月 30 日)的每月并发症发生率轨迹的斜率(斜率比)。
在干预前,心律失常导致的并发症发生率增加,急性冠状动脉综合征(ACS)和全因死亡率降低,但心脏骤停和心力衰竭以及肺水肿的发生率保持不变。对整体数据的分析表明,干预后心脏和 ACS 并发症的发生率有所下降,但医院总死亡率没有显著变化。按年龄类别分析显示,80 岁以上年龄组的心脏骤停(斜率比 0.983,95%CI:0.972-0.994)和 ACS(0.989,95%CI:0.981-0.997)并发症的每月发生率轨迹显著下降。女性的心脏骤停(0.985,95%CI:0.977-0.994)、ACS(0.991,95%CI:0.984-0.998)和心力衰竭(0.993,95%CI:0.986-1.000)并发症的每月发生率下降也有统计学意义。心脏骤停(0.983,95%CI:0.969-0.996)、ACS(0.991,95%CI:0.982-1.000)和心律失常(0.996,95%CI:0.994-0.998)的并发症发生率也显著下降。
引入国家标准用于治疗恶化的住院患者与减少急性医院中的院内心脏骤停和急性冠状动脉综合征的发生率有关。最大的益处见于老年人、女性和手术患者。