Thuesen B, Schaffalitzky de Muckadell O B, Holst J J, Bahnsen M
Am J Gastroenterol. 1987 Aug;82(8):723-6.
The concentrations of secretin and somatostatin in plasma were measured in 10 healthy subjects during a 4-day fast. The fast induced increased concentrations of plasma secretin (from 1.2 +/- 0.5 to 9.5 +/- 2.3 pmol/l) and somatostatin (from 5.2 +/- 1.5 to 8.6 +/- 1.7 pmol/l). Gastric aspiration for 1 h suppressed the high concentrations of secretin by 46% and somatostatin by 27%. The intravenous infusion of glucose reduced the plasma secretin even further by 88%; the decrease in somatostatin was not statistically significant. The study shows that gastric aspiration and/or glucose infusion suppressed the high plasma concentration of secretin and that factors other than hyperchlorhydria must be involved in the hypersecretinemia seen during starvation. The elevated plasma somatostatin concentration seen during starvation may be a consequence of increased acid secretion.
在10名健康受试者为期4天的禁食期间，测定了血浆中促胰液素和生长抑素的浓度。禁食导致血浆促胰液素浓度升高（从1.2±0.5皮摩尔/升升至9.5±2.3皮摩尔/升）以及生长抑素浓度升高（从5.2±1.5皮摩尔/升升至8.6±1.7皮摩尔/升）。1小时的胃抽吸使促胰液素的高浓度降低了46%，生长抑素降低了27%。静脉输注葡萄糖使血浆促胰液素进一步降低了88%；生长抑素的降低无统计学意义。该研究表明，胃抽吸和/或葡萄糖输注抑制了血浆促胰液素的高浓度，并且除胃酸过多外的其他因素必定参与了饥饿期间出现的促胰液素血症。饥饿期间血浆生长抑素浓度升高可能是胃酸分泌增加的结果。
