Scheeres D E, DeKryger L L, Dean R E
Am Surg. 1987 Jul;53(7):392-5.
This retrospective study was undertaken to determine if the advent of H2 blockers has altered the surgical treatment and outcome of patients with peptic ulcer disease (PUD). The records of patients having surgery for PUD at Butterworth Hospital, Grand Rapids, Michigan, from 1971-73 (Group 1) and 1981-83 (Group 2) were reviewed. Data recorded included patient and disease characteristics, surgical procedures, morbidity, and mortality. There was a significant difference in mean age: 54 years in Group 1 and 60 years in Group 2. Group 2 had a higher incidence of concomitant medical illnesses. Indications for operation were predominantly of an emergent nature in Group 2, with a marked decline in elective surgeries from 75 per cent to 55 per cent. There was a 15 per cent incidence of nonsurgical complications in Group 2, as opposed to 9 per cent in Group 1. This study demonstrates that the use of H2 blockers and changes in patient characteristics have altered the surgical treatment and outcome of patients with PUD.
本回顾性研究旨在确定H2阻滞剂的出现是否改变了消化性溃疡疾病（PUD）患者的手术治疗方式及预后。对1971年至1973年期间（第1组）以及1981年至1983年期间（第2组）在密歇根州大急流城巴特沃思医院接受PUD手术治疗的患者记录进行了回顾。记录的数据包括患者及疾病特征、手术方式、发病率和死亡率。两组患者的平均年龄存在显著差异：第1组为54岁，第2组为60岁。第2组合并内科疾病的发生率更高。第2组的手术指征主要为急症性质，择期手术从75%显著下降至55%。第2组非手术并发症的发生率为15%，而第1组为9%。本研究表明，H2阻滞剂的使用以及患者特征的变化改变了PUD患者的手术治疗方式及预后。
