School of Science and Engineering, Sharif University of Technology-International Campus, Kish, Iran.
School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Biomech Model Mechanobiol. 2018 Feb;17(1):205-221. doi: 10.1007/s10237-017-0955-x. Epub 2017 Aug 31.
Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid-solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle-particle interactions. Our results state that the number of spherical particles migrating towards the region of lumen with potential of thrombus existence (PTE) rises by increasing the particle size. Also, an optimum scope of particle size in which the adhesive probability parameter reaches its maximum was determined. We acquired an optimum scope for a specific degree of particle sphericity in which the thrombus surfaces experience the maximum density of interaction with particles. We learned that the ligand-receptor mechanism-based drug carriers are better choices for treating LAD arterial diseases when the addressees are patients with low haematocrit-related diseases. While due to the amount of shear stress exerting on the diseased area, generally exploiting nanoshear-activated drug carriers would be the more effective option when it comes to the thrombolytic therapies of patients with high haematocrit-related diseases.
左前降支（LAD）的阻塞是由于血栓或粥样硬化斑块引起的，这是全球死亡的主要原因。通过微纳米粒子将药物靶向递送至病变部位是开发新的溶栓或治疗再狭窄策略的非常有前途的方法。在这项工作中，我们通过流固耦合方法并基于生理边界条件对特定患者的重建 LAD 动脉中的血流特征进行建模。接下来，我们考虑到布朗运动和粒子-粒子相互作用，提供了微纳米粒子在血流中动力学的拉格朗日描述。我们的结果表明，随着颗粒尺寸的增加，向存在血栓潜在区域（PTE）的管腔迁移的球形颗粒数量增加。此外，还确定了颗粒尺寸的最佳范围，在此范围内，粘附概率参数达到最大值。我们获得了一个特定的颗粒球度最佳范围，其中血栓表面与颗粒发生最大密度的相互作用。我们了解到，当治疗对象是低血细胞比容相关疾病的患者时，基于配体-受体机制的药物载体是治疗 LAD 动脉疾病的更好选择。然而，由于剪切应力对病变区域的影响，对于高血细胞比容相关疾病患者的溶栓治疗，通常利用纳米剪切激活药物载体将是更有效的选择。
