Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats.
作者信息
Baumeister A A, Hawkins M F, Anticich T G, Moore L L, Higgins T D
出版信息
Brain Res. 1987 May 12;411(1):183-6. doi: 10.1016/0006-8993(87)90698-6.
PMID:2886181
Abstract
Bilateral intranigral microinjection of morphine produced dose-related and naloxone-reversible antinociceptive effects on the tail-flick and hot-plate tests. Intranigral injection of enkephalin had antinociceptive effects on both tests, and dynorphin had an antinociceptive effect on the hot-plate test. This is the first report of evidence that nigral opiate receptors may mediate antinociception.
摘要
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