双侧黑质内微量注射吗啡和阿片肽可使大鼠产生抗伤害感受作用。
Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats.
作者信息
Baumeister A A, Hawkins M F, Anticich T G, Moore L L, Higgins T D
出版信息
Brain Res. 1987 May 12;411(1):183-6. doi: 10.1016/0006-8993(87)90698-6.
PMID:2886181
Abstract
Bilateral intranigral microinjection of morphine produced dose-related and naloxone-reversible antinociceptive effects on the tail-flick and hot-plate tests. Intranigral injection of enkephalin had antinociceptive effects on both tests, and dynorphin had an antinociceptive effect on the hot-plate test. This is the first report of evidence that nigral opiate receptors may mediate antinociception.
摘要
双侧黑质内微量注射吗啡在甩尾试验和热板试验中产生了剂量相关且可被纳洛酮逆转的抗伤害感受作用。黑质内注射脑啡肽在这两项试验中均有抗伤害感受作用，而强啡肽在热板试验中有抗伤害感受作用。这是关于黑质阿片受体可能介导抗伤害感受的证据的首次报道。
Zotero 插件