Gein S V, Gavrilova T V, Gein O N, Nikitina L S, Chereshneva M V, Chereshnev V A, Kirilina E A
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.
Perm State National Research University, Perm, Russia.
Dokl Biol Sci. 2017 Jul;475(1):154-156. doi: 10.1134/S0012496617040123. Epub 2017 Sep 1.
In mice, two-hour immobilization stress inhibited zymosan-induced production by macrophages of the oxygen radicals and cytokine IL-1β. After myelopeptides MP-5 and MP-6 were administered into mice, the stress-induced inhibition of the reactive oxygen species (ROS) and IL-1β was abrogated. MP-5 peptide stimulated spontaneous ROS production by macrophages and reduced IL-10 production under stress. Thus, under in vivo conditions and under stress, the effect of MP-5 and MP-6 myelopeptides modulates the peritoneal macrophage activity.
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