Metal-Ligand Cooperative Reactivity in the (Pseudo)-Dearomatized PN(P) Systems: The Influence of the Zwitterionic Form in Dearomatized Pincer Complexes.

The concept of aromaticity in pincer ligands and complexes was discussed in order to provide insights into their metal-ligand cooperative activities. The aromatic PN(P) and dearomatized PN(P)* pincer ligands and the corresponding transition metal complexes were studied with the nucleus-independent chemical shift (NICS), anisotropy of the current (induced) density (ACID), isochemical shielding surfaces (ICSS), harmonic oscillator model of aromaticity (HOMA), MCBO, Shannon aromaticity, and natural bond order (NBO) analyses. The study on the model systems showed that for the dearomatized species the decrease of the NICS(1) value comes with the larger contribution of the aromatic zwitterionic mesomeric form. In all examples, the incorporation of the metal center into the pincer ligand decreases the NICS(1) values. The DFT calculations support the dearomatized pyridine ring in PNP* or PNN* ligand indeed being nonaromatic, in contrast to the PN(P)* ligand which has partial aromatic character due to the larger contribution of the zwitterionic resonance structure. The difference in aromaticity between the rings contributes to the thermodynamic balance of the metal ligand cooperative reactions, changing the energetics of the process when different dearomatized pincer ligands are used. This was further exemplified by aromaticity analysis of the heterolytic hydrogen cleavage reaction of ruthenium PNN complexes of Milstein and the PN of Huang, with similar geometries but distinctive thermodynamic preference.