Peng Kang, Peng Yu-Jie, Wang Jing, Yang Ming-Jian, Fu Zi-Ying, Tang Jia, Chen Qi-Cai
School of Life Sciences and Hubei Key Lab of Genetic Regulation & Integrative Biology, Central China Normal University, Wuhan, China.
PLoS One. 2017 Sep 1;12(9):e0184097. doi: 10.1371/journal.pone.0184097. eCollection 2017.
In the auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from the lower auditory nuclei, contralateral IC, and auditory cortex (AC), and then uploads these inputs to the thalamus and cortex. Meanwhile, the AC modulates the sound signal processing of IC neurons, including their latency (i.e., first-spike latency). Excitatory and inhibitory corticofugal projections to the IC may shorten and prolong the latency of IC neurons, respectively. However, the synaptic mechanisms underlying the corticofugal latency modulation of IC neurons remain unclear. Thus, this study probed these mechanisms via in vivo intracellular recording and acoustic and focal electric stimulation. The AC latency modulation of IC neurons is possibly mediated by pre-spike depolarization duration, pre-spike hyperpolarization duration, and spike onset time. This study suggests an effective strategy for the timing sequence determination of auditory information uploaded to the thalamus and cortex.
在听觉通路中，下丘（IC）接收并整合来自低位听觉核团、对侧下丘和听觉皮层（AC）的兴奋性和抑制性输入，然后将这些输入上传至丘脑和皮层。同时，听觉皮层调节下丘神经元的声音信号处理，包括其潜伏期（即首次放电潜伏期）。向IC的兴奋性和抑制性皮质传出投射可能分别缩短和延长下丘神经元的潜伏期。然而，IC神经元皮质传出潜伏期调制的突触机制仍不清楚。因此，本研究通过体内细胞内记录以及声学和局部电刺激来探究这些机制。听觉皮层对IC神经元潜伏期的调制可能由放电前去极化持续时间、放电前超极化持续时间和放电起始时间介导。本研究提出了一种用于确定上传至丘脑和皮层的听觉信息时间序列的有效策略。
