Schoenfeld N, Mamet R, Epstein O, Lahav M, Lurie Y, Atsmon A
Eur J Biochem. 1987 Aug 3;166(3):663-6. doi: 10.1111/j.1432-1033.1987.tb13564.x.
Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one-third and two-third hepatectomized rats increased 1.5-fold and 2.7-fold and the activity of porphobilinogen deaminase increased 2-fold and 4-fold and was inversely correlated with ferrochelatase activity. delta-Aminolevulinic acid synthase and delta-aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.
对再生大鼠肝脏的血红素合成酶、卟啉和血红素含量进行了检测。在再生的头三天，三分之一肝切除和三分之二肝切除大鼠的肝脏重量分别增加了1.5倍和2.7倍，胆色素原脱氨酶的活性分别增加了2倍和4倍，且与亚铁螯合酶活性呈负相关。δ-氨基-γ-酮戊酸合成酶和δ-氨基-γ-酮戊酸脱水酶的活性降低。同时观察到卟啉浓度增加而血红素浓度降低。本文讨论了肝脏快速生长过程中血红素生物合成途径的变化。
